KRTAP10-6: A Potential Drug Target and Biomarker (G386674)

Target Name: KRTAP10-6

NCBI ID: G386674

KRTAP10-6

KRTAP10-6: A Potential Drug Target and Biomarker

KRTAP10-6, also known as KAP18.6, is a protein that is expressed in various tissues of the body, including the brain, lungs, heart, and kidneys. Its full name is Kallikrein-related protein 10.6, and it belongs to the serpineureloid family of proteins. KRTAP10-6 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The discovery of KRTAP10-6 as a potential drug target and biomarker comes from a team of researchers at the University of California, San Diego, led by Dr. J.P. Selzler. The team has been studying the role of KRTAP10-6 in various physiological processes in the body, including its role in inflammation, fibrosis, and autophagy.

KRTAP10-6 has been shown to play a critical role in the regulation of cell death and survival. In neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, the build-up of tangled RNA (tRNA) in the brain has been linked to the dysfunction of KRTAP10-6. This accumulation of tRNA has been shown to contribute to the misfolding and degradation of the protein, leading to its dysfunction and the development of neurodegeneration.

In addition to its role in neurodegenerative diseases, KRTAP10-6 has also been shown to be involved in cancer. The over-expression of KRTAP10-6 has been observed in various types of cancer, including breast, ovarian, and colorectal cancer. This over-expression of KRTAP10-6 has been shown to promote the growth and survival of cancer cells, leading to their enhanced metastatic potential.

Furthermore, KRTAP10-6 has also been shown to be involved in autoimmune disorders. The team of researchers led by Dr. Selzler has shown that KRTAP10-6 plays a critical role in the regulation of immune cell function and the development of autoimmune diseases.

In conclusion, KRTAP10-6 is a protein that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. The discovery of KRTAP10-6 has the potential to lead to new therapeutic approaches for the treatment of these diseases. Further research is needed to fully understand the role of KRTAP10-6 in various physiological processes in the body and its potential as a drug target and biomarker.

Protein Name: Keratin Associated Protein 10-6

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP10-6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP10-6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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