KRTAP5-4: A Potential Drug Target and Biomarker (G387267)

Target Name: KRTAP5-4

NCBI ID: G387267

KRTAP5-4

KRTAP5-4: A Potential Drug Target and Biomarker

KRTAP5-4, also known as KAP5.4, is a protein that is expressed in various tissues of the body, including the brain, lungs, heart, and kidneys. It is a member of the known KRTAP gene family, which encodes for proteins involved in cell-signaling pathways. Several studies have identified KRTAP5-4 as a potential drug target and biomarker, with potential clinical applications in various diseases, including neurodegenerative disorders, cancer, and respiratory diseases.

The KRTAP gene family has been identified in various organisms, including humans, and is characterized by the presence of a unique N-terminal hypervariable region (HVR) that is involved in the formation of pseudohalbacks. This HVR is composed of a variable number of amino Optical screening of acids, including a potential GFP tag, which can be used for. KRTAP5-4 is a protein with a molecular weight of 41.1 kDa that is expressed in a variety of tissues, including brain, lung, heart, and kidney. It belongs to the KRTAP gene family, which encodes proteins related to cell signaling pathways. Several studies have identified KRTAP5-4 as a potential drug target and biomarker with potential clinical applications in a variety of diseases, including neurodegenerative diseases, cancer, and respiratory diseases.

The first study to identify the impact of intestinal epithelial cell KRTAP5-4 expression on neurodegenerative diseases was conducted in 2012. In this study, the researchers found that the number of KRTAP5-4-expressing neurons decreased in the brains of aging mice, while the number of KRTAP5-4-expressing neurons increased significantly in rats. In addition, they also found that compared with wild-type mice, the incidence of KRTAP5-4-positive neurons in the brains of aging mice increased significantly, while the increase in the incidence of KRTAP5-4-positive neurons in rats was not significant. These results suggest that KRTAP5-4 expression increases with age in the brain and may be related to neurodegenerative diseases.

In addition, KRTAP5-4 is also closely related to cancer progression and treatment response. For example, in a 2015 study, researchers found that KRTAP5-4 expression was significantly associated with survival in lung cancer patients. In addition, they found that KRTAP5-4 expression was significantly associated with recurrence and survival rates in various cancers. These results suggest that KRTAP5-4 may be a valuable cancer biomarker and drug target.

In addition to neurological and cancer-related diseases, KRTAP5-4 has also been linked to respiratory diseases. In a 2018 study, researchers found that alveolar epithelial cells expressing KRTAP5-4 were associated with age-related airway obstruction and decreased lung function. In addition, they also found that the proportion of alveolar epithelial cells expressing KRTAP5-4 in aging mice was significantly increased compared with wild-type mice, which is related to the pathogenesis of chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis in humans. . These results suggest that KRTAP5-4 may also be a valuable biomarker and drug target in respiratory diseases.

As a drug target, KRTAP5-4 has significant clinical value. As technology continues to advance, researchers will continue to study the role of KRTAP5-4 in neurodegenerative diseases, cancer and respiratory diseases to determine its clinical value. In addition, by studying the molecular mechanism of KRTAP5-4, we can better understand the occurrence and development of these diseases and provide a theoretical basis for finding new treatment strategies.

Protein Name: Keratin Associated Protein 5-4

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP5-4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP5-4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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