PDE4C: A Potential Drug Target and Biomarker for Phosphodiesterase-4C

Target Name: PDE4C

NCBI ID: G5143

PDE4C

Other Name(s): Phosphodiesterase-4C, cAMP-specific (dunce (Drosophila)-homolog) | phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila) | CAMP-specific 3',5'-cyclic phosphodiesterase 4

PDE4C: A Potential Drug Target and Biomarker for Phosphodiesterase-4C

Phosphodiesterase-4C (PDE4C) is a protein that plays a crucial role in cellular signaling and metabolism. It is a member of the superfamily of cAMP-dependent protein kinases (PDE4C/PDE4C-like) and is involved in the regulation of various cellular processes, including intracellular signaling, DNA replication, and metabolism. PDE4C has also been implicated in several diseases, including cancer, neurodegenerative diseases, and developmental disorders. As a result, it is a promising target for drug development.

The protein encoded by the PDE4C gene is a 120-kDa protein that consists of 414 amino acid residues. PDE4C is highly conserved and has a molecular weight of 40.9 kDa. It has a unique structure that is composed of a catalytic domain, a transmembrane region, and an optional C-terminal region. The catalytic domain is the most conserved part of the protein and is responsible for the catalytic activity of PDE4C. It consists of a catalytic cycle and a catalytic terminal region that contain the active site for cAMP binding and catalytic activity.

The transmembrane region of PDE4C is responsible for its membrane association and its ability to interact with various intracellular signaling pathways. It has been shown to be involved in several intracellular signaling pathways, including the cAMP-dependent signaling pathway, the protein kinase A (PKA) pathway, and the mitogen-activated protein kinase (MAPK) pathway. PDE4C is also known to be involved in the regulation of DNA replication and metabolism, including the DNA damage response and gene expression.

In addition to its role in intracellular signaling, PDE4C is also implicated in several diseases. For example, PDE4C has been shown to be involved in the development and progression of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. It has also been linked to the development of cancer, including breast and ovarian cancer. In addition, PDE4C has been shown to be involved in the regulation of development and behavior, including the timing of neuronal proliferation and differentiation.

Given its involvement in several cellular processes, PDE4C is a promising target for drug development. Many drugs that have been developed to target other protein kinases, including PKA and MAPK, have been shown to be effective in treating various diseases. Therefore, it is possible that PDE4C may also be a drug target.

One approach to targeting PDE4C is to develop small molecules that can inhibit its catalytic activity. Such compounds would be useful for treating diseases that are caused by the over-activity of PDE4C, such as cancer and neurodegenerative diseases. Additionally, drugs that can modulate PDE4C activity levels could also be useful for treating these diseases.

Another approach to targeting PDE4C is to develop antibodies that can specifically recognize and bind to it. These antibodies could be used to treat diseases that are caused by the over-activity of PDE4C, such as cancer and neurodegenerative diseases. Additionally, antibodies that can block the effects of PDE4C could also be useful for treating these diseases.

In conclusion, PDE4C is a protein that plays a crucial role in cellular signaling and metabolism. It is involved in several intracellular signaling pathways and has been implicated in several diseases. As a result, it is a promising target for drug development. The development of small molecules and antibodies that can inhibit or modulate PDE4C activity could be useful for treating various diseases. Further research is needed to fully understand the role of PDE4C in cellular signaling and to develop effective treatments.

Protein Name: Phosphodiesterase 4C

Functions: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes

The "PDE4C Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDE4C comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets