Phosphodiesterase PDE5A: Key Enzyme in DNA Damage Repair (G8654)

Target Name: PDE5A

NCBI ID: G8654

PDE5A

Phosphodiesterase PDE5A: Key Enzyme in DNA Damage Repair

Phosphodiesterase isozyme 5 (PDE5A) is a protein that is expressed in various tissues throughout the body. It is a key enzyme in the DNA damage repair pathway, which is responsible for repairing damage to DNA that can occur due to various factors such as mutation, UV radiation, and chemicals. PDE5A plays a crucial role in ensuring that the DNA is repaired and the cell is able to continue to function properly.

PDE5A is a protein that is expressed in many different tissues throughout the body, including the brain, heart, liver, and muscle. It is also highly expressed in cancer cells, which allows it to be identified as a potential drug target.

The Role of PDE5A in DNA Damage Repair

PDE5A is a key enzyme in the DNA damage repair pathway. When DNA is damaged, PDE5A is responsible for repairing the damage and ensuring that the cell is able to continue to function properly.

PDE5A works by using a unique mechanism to repair DNA damage. It is able to recognize the damage and then adds a phosphate group to the ends of the damaged DNA strand. This phosphate group serves as a template for a new DNA strand to be synthesized, which is then inserted into the damaged strand.

PDE5A's Role in Cancer

PDE5A is also highly expressed in cancer cells, which makes it an attractive drug target. Cancer cells have the ability to repair DNA damage, but they do not have a reliable repair system like healthy cells do. This makes them more susceptible to damage caused by chemotherapy and other treatments. By inhibiting PDE5A, researchers have been able to cause cancer cells to undergo DNA damage that cannot be repaired, which can lead to the development of new cancerous tumors.

PDE5A is also a potential biomarker for cancer. Since it is highly expressed in cancer cells, it can be used as an indicator of the disease. This makes it an attractive target for researchers to study and develop new treatments for cancer.

PDE5A's Role in Genomics

PDE5A is also involved in genomics research. Because it plays a key role in the DNA damage repair pathway, it can be used as an indicator of gene repair and damage, providing very valuable information for studying the molecular mechanisms of DNA repair and damage.

Conclusion

PDE5A is a protein that plays a crucial role in the DNA damage repair pathway. It is highly expressed in various tissues throughout the body, including the brain, heart, liver, and muscle, and is also highly expressed in cancer cells. By inhibiting PDE5A , researchers have been able to cause cancer cells to undergo DNA damage that cannot be repaired, which can lead to the development of new cancerous tumors. PDE5A is also a potential biomarker for cancer and a target for new treatments. Further research is needed to fully understand the role of PDE5A in genomics and its potential as a drug.

Protein Name: Phosphodiesterase 5A

Functions: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334)

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