Pleckhh1: A Protein Target for Various Diseases (G57475)

Target Name: PLEKHH1

NCBI ID: G57475

PLEKHH1

Other Name(s): pleckstrin homology, MyTH4 and FERM domain containing H1 | PKHH1_HUMAN | pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 | PH domain-containing family H member 1 | Pleckstrin homology, MyTH4 and FERM domain containing H1 | KIAA1200 | Pleckstrin homology domain-containing family H member 1

Pleckhh1: A Protein Target for Various Diseases

PLEKHH1, also known as pleckstrin homology, MyTH4, and FERM domain containing H1, is a protein that plays a crucial role in various cellular processes. It is a member of the P-type cation transporter (PCT) family and is expressed in many different tissues and cells, including neurons, muscle cells, and blood vessels.

Pleckstrin homology is a unique protein that is characterized by the presence of a P-type cation transporter (PCT) domain and a MyTH4 gene family-like (MYTH4) domain. The PCT domain is responsible for the transport of various types of ions, including potassium and calcium ions, while the MYTH4 gene family-like domain is involved in protein-protein interactions and may be involved in the regulation of various cellular processes.

One of the most interesting aspects of PLEKHH1 is its potential as a drug target. The PCT domain of PLEKHH1 has been shown to be involved in the regulation of ion transport and has been identified as a potential drug target for various diseases, including heart failure, hypertension, and diabetes.

In addition to its potential as a drug target, PLEKHH1 has also been identified as a biomarker for various diseases. The PLEKHH1 gene is downregulated in various diseases, including heart failure, and has been shown to be involved in the regulation of cellular processes that are related to these diseases. This suggests that PLEKHH1 may be a useful biomarker for the diagnosis and treatment of these diseases.

Another promising aspect of PLEKHH1 is its role in the regulation of cellular processes that are important for brain development and function. PLEKHH1 has been shown to be involved in the regulation of ion transport in the cerebellum, which is responsible for motor coordination and movement. This suggests that PLEKHH1 may be a useful target for the treatment of cerebellum injuries or diseases.

In conclusion, PLEKHH1 is a protein that plays a crucial role in various cellular processes and has been shown to be involved in the regulation of ion transport, protein-protein interactions, and cellular processes that are important for brain development and function. Its potential as a drug target and biomarker make it an attractive target for further research and development. Further studies are needed to fully understand the role of PLEKHH1 in various diseases and to develop effective treatments.

Protein Name: Pleckstrin Homology, MyTH4 And FERM Domain Containing H1

The "PLEKHH1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHH1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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