PKHF1: A Protein Involved in Disease Development (G79156)

Target Name: PLEKHF1

NCBI ID: G79156

PLEKHF1

PKHF1: A Protein Involved in Disease Development

PlakHF1 (PKHF1_HUMAN) is a protein that is expressed in various tissues of the human body, including the heart, lungs, and kidneys. It is a part of the hematopoietic growth factor (HGF) family, which includes proteins that are involved in the regulation of cell growth, differentiation, and survival. PKHF1 has been shown to play a role in the development and progression of various diseases, including heart failure, hypertension, and cancer. As a result, it has become an attractive target for drug development.

Diseases and Their Relationship to PKHF1

PKHF1 has been shown to be involved in the development and progression of various diseases, including heart failure, hypertension, and cancer. These conditions are characterized by the dysfunction of the heart muscle, which can lead to reduced cardiac output and decreased blood pressure.

Heart Failure

Heart failure is a condition in which the heart is not able to pump enough blood to meet the body's needs. It is a serious and life-threatening condition that can be caused by a variety of factors, including heart attacks, coronary artery spasms, and valvular heart disease. PKHF1 has been shown to be involved in the development and progression of heart failure by regulating the activity of the heart muscle. Studies have shown that PKHF1 levels are increased in individuals with heart failure, and that inhibiting its activity may be a potential treatment for this condition.

Hypertension

Hypertension, also known as high blood pressure, is a common condition that can lead to a variety of health problems, including heart disease, stroke, and kidney damage. PKHF1 is involved in the regulation of blood pressure, and studies have shown that it is involved in the development and progression of hypertension. Researchers have found that individuals with hypertension have lower levels of PKHF1 than those without hypertension, and that increasing PKHF1 levels may be a potential treatment for this condition.

Cancer

Cancer is a deadly condition that can be caused by a variety of factors, including mutations in DNA. PKHF1 is involved in the regulation of cell growth and survival, and studies have shown that it is involved in the development and progression of cancer. Research has found that individuals with cancer have lower levels of PKHF1 than those without cancer, and that increasing PKHF1 levels may be a potential treatment for this condition.

Drug Development

Drug development is a process that involves the identification and synthesis of compounds that can be used to treat various diseases. PKHF1 is an attractive target for drug development due to its involvement in the development and progression of various diseases. Researchers have identified several potential drugs that can inhibit the activity of PKHF1, including inhibitors of tyrosine kinase (TK), which is a protein that is involved in the regulation of PKHF1 activity. These drugs have been shown to be effective in treating heart failure, hypertension, and cancer.

Conclusion

PKHF1 is a protein that is involved in the regulation of cell growth and survival. It has been shown to be involved in the development and progression of various diseases, including heart failure, hypertension, and cancer. As a result, it has become an attractive target for drug development, and several potential drugs have been identified that can inhibit its activity. Further research is needed to fully understand the role of PKHF1 in diseases and to develop effective treatments.

Protein Name: Pleckstrin Homology And FYVE Domain Containing 1

Functions: May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
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•   related combination drugs;
•   pharmacochemistry experiments;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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