Stem Cells and Cell Signaling: A Potential Drug Target (G55200)

Target Name: PLEKHG6

NCBI ID: G55200

PLEKHG6

Other Name(s): PKHG6_HUMAN | PH domain-containing family G member 6 | myosin interacting guanine nucleotide exchange factor | myosin II interacting GEF | MyoGEF | PLEKHG6 variant 2 | pleckstrin homology and RhoGEF domain containing G6 | Pleckstrin homology domain-containing family G member 6 (isoform a) | Pleckstrin homology domain-containing family G member 6 | pleckstrin homology domain containing, family G (with RhoGef domain) member 6 | Myosin interacting guanine nucleotide exchange factor | Pleckstrin homology and RhoGEF domain containing G6, transcript variant 2 | Myosin-interacting guanine nucleotide exchange factor

Stem Cells and Cell Signaling: A Potential Drug Target

PLEKHG6 (PKHG6_HUMAN) is a gene that encodes a protein known as PLEKHG6. PLEKHG6 is a protein that is expressed in various tissues of the human body, including the brain, heart, and kidneys. It is involved in a number of cellular processes that are essential for normal development and function.

One of the key functions of PLEKHG6 is its role in the development and maintenance of the blood-brain barrier. The blood-brain barrier is a specialized barrier that separates the brain from the surrounding bloodstream. It is designed to protect the brain from harmful substances that could cause injury or disease, but it also makes it difficult for important substances to reach the brain. PLEKHG6 is involved in the formation and maintenance of the blood-brain barrier by regulating the movement of cells through the barrier.

Another important function of PLEKHG6 is its role in the regulation of cell signaling. Signal transduction is the process by which cells respond to signals from the environment. PLEKHG6 is involved in the regulation of several different signaling pathways, including the tyrosine signaling pathway. This pathway is important for the development and maintenance of many different cellular processes, including cell growth, differentiation, and survival.

PLEKHG6 is also involved in the regulation of the cytoskeleton. The cytoskeleton is the structure that gives cells shape and stability. PLEKHG6 is involved in the production and maintenance of the cytoskeleton by regulating the movement of microtubules within the cytoskeleton.

In addition to its role in the blood-brain barrier and cell signaling, PLEKHG6 is also involved in the regulation of a number of other cellular processes. It is involved in the development and maintenance of the nervous system, and it is involved in the regulation of sleep and wakefulness.

Given its involvement in so many important cellular processes, PLEKHG6 is a promising drug target. Researchers are currently working to develop drugs that can specifically target PLEKHG6 and modulate its activity. These drugs may be used to treat a variety of different conditions, including cancer, neurodegenerative diseases, and sleep disorders.

In conclusion, PLEKHG6 is a gene that encodes a protein that is involved in a number of important cellular processes. Its regulation of the blood-brain barrier, cell signaling, and cytoskeleton make it a promising drug target. Further research is needed to develop drugs that can specifically target PLEKHG6 and modulate its activity. These drugs may be used to treat a variety of different conditions and have the potential to improve the health and well-being of many people.

Protein Name: Pleckstrin Homology And RhoGEF Domain Containing G6

Functions: Guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. Also activates RHOG. Does not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving PLEKHG6, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis

The "PLEKHG6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHG6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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