PHD4: A Potential Drug Target and Biomarker (G25894)

Target Name: PLEKHG4

NCBI ID: G25894

PLEKHG4

PHD4: A Potential Drug Target and Biomarker

Pleckstrin homology domain-containing family G member 4 (Pleckstrin homology domain-containing protein 4, PHD4) is a protein that is expressed in various tissues and organs, including brain, heart, and muscle. PHD4 is characterized by the presence of a unique transmembrane domain that is composed of a single alpha helix and a long coiled-coil region. This protein is of interest as a potential drug target or biomarker due to its unique structure and the involvement of various cellular processes.

The PHD4 protein is involved in various cellular processes that are critical for cell survival and function. One of the most significant functions of PHD4 is its role in cell signaling. PHD4 is a member of the Pleckstrin homology domain family, which is a conserved structural motif that is found in various proteins that play important roles in cellular signaling. These domains are characterized by the presence of a transmembrane domain and a conserved carboxylic acid residue that is involved in the formation of a cation-dependent ion channel.

PHD4 is involved in the regulation of a wide range of cellular processes, including cell signaling, cytoskeletal organization, and intracellular transport. One of the most significant functions of PHD4 is its role in the regulation of cell signaling. PHD4 is involved in the regulation of Various signaling pathways, including the TGF-β pathway, which is involved in cell growth, differentiation, and survival.

In addition to its role in cell signaling, PHD4 is also involved in the regulation of cytoskeletal organization. PHD4 is a member of the tubulin family, which is responsible for the regulation of microtubules in cells. These microtubules play a critical role in the organization and movement of cells, and are involved in various cellular processes, including cell signaling.

PHD4 is also involved in the regulation of intracellular transport. PHD4 is a member of the transport domain family, which is responsible for the regulation of the movement of proteins into and out of cells. These transport domains are characterized by the presence of a transmembrane domain and a conserved carboxylic acid residue that is involved in the formation of a cation-dependent ion channel.

PHD4 is also of interest as a potential drug target due to its unique structure and the involvement of various cellular processes. PHD4 is a conserved protein that is expressed in a wide range of tissues and organs, making it an attractive target for drug development. Additionally , the unique structure of PHD4, including its transmembrane domain and conserved carboxylic acid residue, suggests that it may be difficult to develop drug resistance to this protein.

In conclusion, PHD4 is a unique and conserved protein that is involved in various cellular processes. Its role in cell signaling, cytoskeletal organization, and intracellular transport makes it an attractive target for drug development. The transmembrane domain and conserved carboxylic acid residue also suggest that it may be difficult to develop drug resistance to this protein. Further research is needed to fully understand the role of PHD4 in cellular processes and its potential as a drug target.

Protein Name: Pleckstrin Homology And RhoGEF Domain Containing G4

Functions: Possible role in intracellular signaling and cytoskeleton dynamics at the Golgi

The "PLEKHG4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHG4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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