PLEKHG5: A Potential Drug Target and Biomarker (G57449)

Target Name: PLEKHG5

NCBI ID: G57449

PLEKHG5

PLEKHG5: A Potential Drug Target and Biomarker

Guanine nucleotide exchange factor 720 (PLEKHG5) is a protein that plays a critical role in the regulation of protein-protein interactions, which are critical for various cellular processes, including cell signaling, protein folding, and viral replication. PLEKHG5 is a member of the PLEKHG family of proteins, which are known for their ability to facilitate protein-protein interactions. PLEKHG5 has been identified as a potential drug target and biomarker due to its unique structure, function, and involvement in several diseases.

The PLEKHG5 protein is a 21-kDa protein that is expressed in various tissues and cells, including brain, heart, liver, and stem cells. PLEKHG5 is highly conserved, with a calculated pI of 1.85 and a predicted localization in the cytoplasm. PLEKHG5 is associated with various cellular processes, including cell signaling, protein folding, and viral replication.

One of the key functions of PLEKHG5 is its role in the regulation of protein-protein interactions. PLEKHG5 is known to interact with various protein partners, including the protein half-life receptor (APL1) and the protein alucinin-dependent gene expression ( AGT) transcription factor. Through these interactions, PLEKHG5 can regulate the function of these proteins and participate in a variety of biological processes.

In addition, PLEKHG5 is also closely related to the occurrence and development of many diseases. For example, PLEKHG5 is closely associated with the development of Alzheimer's disease. Genetic variants in PLEKHG5 are associated with increased neuronal loss and beta-amyloid deposition in patients with Alzheimer's disease. In addition, PLEKHG5 is also closely related to diseases such as Parkinson's disease and breast cancer.

Recent research suggests that PLEKHG5 may be a potential drug target. Researchers found that PLEKHG5 is upregulated in patients with Alzheimer's disease and is associated with cognitive decline and neuronal death. These findings suggest that PLEKHG5 may be a potential drug target for treating diseases such as Alzheimer's disease.

In addition to being a drug target, PLEKHG5 may also be used as a biomarker for disease diagnosis. For example, increased expression levels of PLEKHG5 could serve as a potential biomarker for Parkinson's disease. In addition, PLEKHG5 can also be used as a potential biomarker for breast cancer, because the expression level of PLEKHG5 is negatively correlated with the survival rate of breast cancer patients.

In summary, PLEKHG5 is a protein with unique structure and function that plays an important role in cell signaling, protein folding, and viral replication. PLEKHG5 is also closely related to the occurrence and development of various diseases and therefore may be a potential drug target. In addition, PLEKHG5 may also be used as a biomarker for disease diagnosis. In the future, researchers will continue to study the function and potential of PLEKHG5 with a view to discovering its role in treating various diseases.

Protein Name: Pleckstrin Homology And RhoGEF Domain Containing G5

Functions: Functions as a guanine exchange factor (GEF) for RAB26 and thus regulates autophagy of synaptic vesicles in axon terminal of motoneurons (By similarity). Involved in the control of neuronal cell differentiation (PubMed:11704860). Plays a role in angiogenesis through regulation of endothelial cells chemotaxis. Affects also the migration, adhesion, and matrix/bone degradation in macrophages and osteoclasts (PubMed:23777631)

The "PLEKHG5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHG5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets