PLEKHM1: Multi-functional Protein Involved in Cell-Signaling, Cell-Death and Tissue Repair

Target Name: PLEKHM1

NCBI ID: G9842

PLEKHM1

PLEKHM1: Multi-functional Protein Involved in Cell-Signaling, Cell-Death and Tissue Repair

PLEKHM1 (B2) is a protein that is expressed in various tissues throughout the body, including the brain, lungs, heart, kidneys, and intestines. It is a member of the PLEK family of proteins, which are known for their role in cell-signaling and inflammation.

One of the key functions of PLEKHM1 is its role in the regulation of cell-cycle progression. PLEKHM1 is involved in the metaphase of the cell cycle, which is the stage at which a cell divides. During this stage, PLEKHM1 helps to ensure that the cell divides correctly and that the new cell is identical to the original.

Another function of PLEKHM1 is its role in the regulation of cell- death. PLEKHM1 has been shown to play a role in the regulation of cell- death, both in the case of cancer and in the case of neurodegenerative diseases. This may be because PLEKHM1 is involved in the production of reactive oxygen species (ROS), which can cause damage to cells and contribute to the development of these diseases.

PLEKHM1 is also involved in the regulation of inflammation. It has been shown to play a role in the regulation of immune responses and in the production of pro-inflammatory cytokines. This may be because PLEKHM1 is involved in the production of chemokines, which are a type of cytokine that can attract immune cells to specific locations in the body.

In addition to its role in cell-cycle progression, regulation of cell- death, and regulation of inflammation, PLEKHM1 is also involved in the regulation of adhesion and migration. It has been shown to play a role in the development and maintenance of tight junctions, which are specialized barriers that help to maintain the integrity of the intercellular space. This may be because PLEKHM1 is involved in the production of tight junctional cadherins, which are proteins that help to maintain the tightness of these barriers.

PLEKHM1 is also involved in the regulation of neural development and function. It has been shown to play a role in the development and maintenance of neural stem cells, which are cells that have the ability to develop into all of the different types of cells in the nervous system. This may be because PLEKHM1 is involved in the production of neurotrophic factors, which are proteins that can support the survival and growth of these stem cells.

In addition to its role in neural development and function, PLEKHM1 is also involved in the regulation of tissue repair and regeneration. It has been shown to play a role in the regulation of the Wnt signaling pathway, which is a critical pathway that helps to maintain the integrity of tissues. This may be because PLEKHM1 is involved in the production of Wnt proteins, which are important for the development and maintenance of tissues.

In conclusion, PLEKHM1 (B2) is a protein that is involved in a wide range of important biological processes in the body. Its functions include cell-cycle progression, regulation of cell- death, regulation of inflammation, regulation of adhesion and migration, regulation of neural development and function, and regulation of tissue repair and regeneration. As a result, PLEKHM1 is an attractive drug target and a potential biomarker for a variety of diseases.

Protein Name: Pleckstrin Homology And RUN Domain Containing M1

Functions: Acts as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Acts as a dual effector of RAB7A and ARL8B that simultaneously binds these GTPases, bringing about clustering and fusion of late endosomes and lysosomes (PubMed:25498145, PubMed:28325809). Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Interaction with Arl8b is a crucial factor in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity)

The "PLEKHM1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PLEKHM1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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