Target Name: NUDT9
NCBI ID: G53343
Review Report on NUDT9 Target / Biomarker Content of Review Report on NUDT9 Target / Biomarker
NUDT9
Other Name(s): ADP-ribose pyrosphosphatase NUDT9 | NUDT9_HUMAN | OTTHUMP00000161163 | NUDT9 alpha | Nucleoside diphosphate-linked moiety X motif 9 | Nudix motif 9 | ADP-ribose pyrophosphatase, mitochondrial | nudix hydrolase 9 | OTTHUMP00000218564 | ADP-ribose ribophosphohydrolase | Nucleoside diphosphate linked moiety X-type motif 9 | ADPR-PPase | ADP-ribose phosphohydrolase | Adenosine diphosphoribose pyrophosphatase | Nudix hydrolase 9, transcript variant 3 | ADP-ribose pyrophosphatase, mitochondrial (isoform c) | Nudix-type motif 9 | ADP-ribose pyrophosphatase, mitochondrial precursor | OTTHUMP00000218562 | NUDT9 variant 1 | ADP-ribose pyrophosphatase | NUDT10 | ADP-ribose diphosphatase | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | NUDT9 variant 3 | OTTHUMP00000218561 | adenosine diphosphoribose pyrophosphatase | MGC3037 | ADP-ribose pyrophosphatase, mitochondrial (isoform a) | nucleoside diphosphate linked moiety X-type motif 9 | Nudix hydrolase 9, transcript variant 1

NUDT9: A Potential Drug Target and Biomarker

NUDT9, also known as NUDT9-GFP, is a nuclear transport protein that is expressed in various tissues and organs, including the brain, heart, and pancreas. Its primary function is to transport neurotransmitters, such as dopamine and GABA, across the blood-brain barrier, allowing them to reach their target cells and play a crucial role in neurotransmission.

Recent studies have identified NUDT9 as a potential drug target and biomarker for various psychiatric and neurological disorders, including Alzheimer's disease, Parkinson's disease, and addiction. Its potential as a drug target is based on its involvement in neurotransmission and its known role in the regulation of neural circuits.

One of the key reasons for the potential of NUDT9 as a drug target is its role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. NUDT9 has been shown to play a critical role in the modification of synaptic plasticity, which is thought to be a key mechanism underlying the development of neuroplasticity and the ability to learn and adapt to new situations.

In addition to its role in synaptic plasticity, NUDT9 has also been shown to be involved in the regulation of neurotransmitter release and uptake. This is important for the proper functioning of neurotransmitters, which are the chemical messengers that transmit signals along the brain's neural circuits.

The potential benefits of targeting NUDT9 with drugs could be significant. By blocking its function as a neurotransport protein, it is possible to reduce the amount of neurotransmitters that reach their target cells, which could lead to therapeutic effects in diseases where excess neurotransmitters are thought to be involved.

One of the key challenges in targeting NUDT9 is its widespread distribution in the brain, which makes it difficult to selectively target it. However, recent advances in imaging techniques, such as optogenetics, have allowed researchers to identify and manipulate NUDT9-GFP in live animals, providing a promising window into its function in the brain.

In addition to its potential as a drug target, NUDT9 has also been identified as a potential biomarker for various psychiatric and neurological disorders. The high level of expression of NUDT9-GFP in the brain suggests that it may be a useful biomarker for tracking the progression of these disorders.

NUDT9-GFP has been shown to be involved in the regulation of neurotransmitter release and uptake, which is important for the proper functioning of neurotransmitters. This suggests that it may be a useful biomarker for disorders that are characterized by changes in the levels of neurotransmitters.

For example, NUDT9 has been shown to play a role in the regulation of dopamine release in the brain, and changes in dopamine levels have been linked to a variety of psychiatric disorders, including Alzheimer's disease and Parkinson's disease. By targeting NUDT9 with drugs that block its function as a neurotransport protein, it is possible to reduce the amount of dopamine that reaches its target cells and potentially treat these disorders.

In addition to its potential as a drug target, NUDT9 has also been shown to be involved in the regulation of neurotransmitter uptake and release. This is important for the proper functioning of neurotransmitters, which are the chemical messengers that transmit signals along the brain's neural circuits.

NUDT9 has been shown to play a role in the regulation of synaptic plasticity, which is the ability of the brain to change and adapt over time. This suggests that it may be a useful biomarker for disorders

Protein Name: Nudix Hydrolase 9

Functions: Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate

The "NUDT9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUDT9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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