Target Name: NUDT7
NCBI ID: G283927
Review Report on NUDT7 Target / Biomarker Content of Review Report on NUDT7 Target / Biomarker
NUDT7
Other Name(s): NUDT7_HUMAN | Nucleoside diphosphate-linked moiety X motif 7 | nudix (nucleoside diphosphate linked moiety X)-type motif 7 | Peroxisomal coenzyme A diphosphatase NUDT7 (isoform 1) | NUDT7 variant 1 | peroxisomal coenzyme A diphosphatase NUDT7 | Peroxisomal coenzyme A diphosphatase NUDT7 | Nudix motif 7 | nudix hydrolase 7 | Nudix hydrolase 7, transcript variant 1

NUDT7: A Potential Drug Target for Cancer

NUDT7, also known as NUDT7-HUMAN, is a protein that is expressed in various tissues of the human body. It is a member of the NUDT7 family, which includes several related proteins that play a role in the regulation of cellular processes such as cell adhesion, migration, and invasion. One of the unique features of NUDT7 is its ability to interact with several different signaling pathways, including the TGF-β pathway and the PI3K/Akt pathway. This makes NUDT7 an attractive target for drug development.

The NUDT7 gene was identified through transcriptomic analysis of human cancer samples. It has been shown to be highly expressed in a variety of human tissues, including brain, lung, and colon. NUDT7 has also been shown to be involved in several cellular processes, including cell adhesion, migration, and invasion.

One of the unique features of NUDT7 is its ability to interact with several different signaling pathways. It has been shown to play a role in the regulation of TGF-β signaling, which is a critical pathway that regulates cell growth, differentiation, and survival. NUDT7 has also been shown to interact with the PI3K/Akt signaling pathway, which is involved in the regulation of cell signaling pathways. This makes NUDT7 a potential target for drugs that target these pathways.

In addition to its potential role in cellular signaling pathways, NUDT7 has also been shown to be involved in several other cellular processes. For example, it has been shown to play a role in the regulation of cell cycle progression, which is the process by which cells grow, divide, and replicate themselves. NUDT7 has also been shown to be involved in the regulation of cell apoptosis, which is the process by which cells die when they are no longer needed.

NUDT7 has also been shown to be involved in several different types of cancer, including breast, lung, and ovarian cancer. These cancer types are particularly aggressive and have a high mortality rate, making them an attractive target for drug development.

Despite its potential as a drug target, NUDT7 is still a relatively unstudied protein. There are currently few studies that have specifically investigated the role of NUDT7 in cancer. However, these studies suggest that NUDT7 may be a promising target for drug development.

In conclusion, NUDT7 is a protein that has been shown to play a role in several cellular processes, including TGF-β and PI3K/Akt signaling pathways. Its unique ability to interact with these pathways makes NUDT7 an attractive target for drug development. Further studies are needed to fully understand the role of NUDT7 in cancer and to develop effective drugs that target this protein.

Protein Name: Nudix Hydrolase 7

Functions: Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity)

The "NUDT7 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUDT7 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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