Target Name: NUDT21
NCBI ID: G11051
Review Report on NUDT21 Target / Biomarker Content of Review Report on NUDT21 Target / Biomarker
NUDT21
Other Name(s): CPSF 25 kDa subunit | CFIm25 | cleavage and polyadenylation specific factor 5, 25 kD subunit | cleavage factor Im complex 25 kDa subunit | cleavage and polyadenylation specificity factor 25 kDa subunit | nudix hydrolase 21 | Cleavage and polyadenylation specificity factor subunit 5 | CPSF5 | CPSF5_HUMAN | nucleoside diphosphate-linked moiety X motif 21 | Cleavage factor Im complex 25 kDa subunit | pre-mRNA cleavage factor Im, 25kD subunit | pre-mRNA cleavage factor Im 25 kDa subunit | pre-mRNA cleavage factor Im 68 kDa subunit | Pre-mRNA cleavage factor Im 68 kDa subunit | cleavage and polyadenylation specific factor 5, 25 kDa | nudix motif 21 | Pre-mRNA cleavage factor Im, 25kD subunit | Nudix hydrolase 21 | nudix (nucleoside diphosphate linked moiety X)-type motif 21 | CFIM25 | Pre-mRNA cleavage factor Im (25kD) | Nucleoside diphosphate-linked moiety X motif 21 | Cleavage and polyadenylation specificity factor 25 kDa subunit | Nudix motif 21 | pre-mRNA cleavage factor Im (25kD) | Cleavage and polyadenylation specific factor 5, 25 kD subunit

Understanding The NUDT21 Subunit: A Potential Drug Target and Biomarker

The NUDT21 subunit is a protein that is expressed in various tissues and cells in the body. It is a key component of the cytoskeleton and plays a significant role in the structure and function of cells. The NUDT21 subunit is also known as the CPSF 25 kDa subunit, and it has been identified as a potential drug target and biomarker.

The cytoskeleton is a complex system of filaments and proteins that provide structural support to cells and help maintain their shape. The NUDT21 subunit is one of the key components of the cytoskeleton and is involved in the formation of the microtubules that give cells their characteristic shape. The NUDT21 subunit is composed of two transmembrane domains and a cytoplasmic tail.

The NUDT21 subunit is expressed in a variety of tissues and cells in the body, including muscle, nerve, and brain cells. It is also expressed in various organs and tissues, such as the heart, lungs, and kidneys. The NUDT21 subunit is involved in many different cellular processes, including cell division, growth, and survival.

One of the key functions of the NUDT21 subunit is its role in cell division. The NUDT21 subunit is involved in the formation of the mitotic spindle, which is the structure that pulls the chromosomes apart during cell division. The NUDT21 subunit is also involved in the regulation of cell growth, as it has been shown to play a role in the regulation of cell proliferation.

In addition to its role in cell division, the NUDT21 subunit is also involved in the regulation of cell survival. The NUDT21 subunit has been shown to play a role in the regulation of cell survival by maintaining the stability of the cytoskeleton. This is important for the survival and proliferation of cells, as a stable cytoskeleton provides structural stability and helps maintain the integrity of the cell.

The NUDT21 subunit has also been identified as a potential drug target and biomarker. The NUDT21 subunit is thought to be a good candidate for drug targeting due to its involvement in multiple cellular processes that are important for cellular survival and division. In addition, the NUDT21 subunit has been shown to be a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and cardiovascular disease.

The NUDT21 subunit has also been shown to play a role in the regulation of cellular signaling pathways. It has been shown to be involved in the regulation of the TGF-β pathway, a signaling pathway that is important for cell growth, differentiation, and survival. The NUDT21 subunit has also been shown to play a role in the regulation of the Wnt pathway, a signaling pathway that is important for cell growth and development.

In conclusion, the NUDT21 subunit is a protein that is expressed in various tissues and cells in the body. It is a key component of the cytoskeleton and plays a significant role in the structure and function of cells. The NUDT21 subunit is also known as the CPSF 25 kDa subunit, and it has been identified as a potential drug target and biomarker. Further research is needed to fully understand the role of the NUDT21 subunit in cellular processes and its potential as a drug target and biomarker.

Protein Name: Nudix Hydrolase 21

Functions: Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:15937220, PubMed:17024186, PubMed:17098938, PubMed:29276085). CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals) (PubMed:9659921, PubMed:8626397, PubMed:14690600, PubMed:17024186). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation (PubMed:17098938, PubMed:23187700, PubMed:29276085). The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs (PubMed:17098938, PubMed:20695905, PubMed:29276085). NUDT21/CPSF5 activates indirectly the mRNA 3'-processing machinery by recruiting CPSF6 and/or CPSF7 (PubMed:29276085). Binds to 5'-UGUA-3' elements localized upstream of pA signals that act as enhancers of pre-mRNA 3'-end processing (PubMed:8626397, PubMed:14690600, PubMed:15169763, PubMed:17024186, PubMed:22813749, PubMed:20479262). The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA (PubMed:20479262, PubMed:21295486). Plays a role in somatic cell fate transitions and pluripotency by regulating widespread changes in gene expression through an APA-dependent function (By similarity). Binds to chromatin (By similarity). Binds to, but does not hydrolyze mono- and di-adenosine nucleotides (PubMed:18445629)

The "NUDT21 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUDT21 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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