Target Name: NUDT5
NCBI ID: G11164
Review Report on NUDT5 Target / Biomarker Content of Review Report on NUDT5 Target / Biomarker
NUDT5
Other Name(s): Nucleoside diphosphate-linked moiety X motif 5 | ADP-sugar pyrophosphatase | hNUDT5 | Nudix motif 5 | Nudix hydrolase 5, transcript variant 1 | nudix (nucleoside diphosphate linked moiety X)-type motif 5 | YSA1 | nuclear ATP-synthesis protein NUDIX5 | YSAH1 | nudix hydrolase 5 | OTTHUMP00000019112 | Nucleoside diphosphate linked moiety X-type motif 5 | NUDT5 variant 1 | ADP-sugar pyrophosphatase (isoform 1) | 8-oxo-dGDP phosphatase | YSA1H | hYSAH1 | NUDT5_HUMAN | Nuclear ATP-synthesis protein NUDIX5

NUDT5: A Potential Drug Target and Biomarker

Nucleoside diphosphate-linked moiety X (NUDT5) is a unique protein that has been identified as a potential drug target and biomarker. NUDT5 is a non-coding RNA molecule that plays a critical role in various cellular processes, including gene regulation, DNA replication, and cell survival. The protein encoded by NUDT5 has been shown to have various functions, including promoting the association of DNA with histone histone-like protein,72 participating in the repair of DNA damage,81 and regulating cell growth and apoptosis.82

The NUDT5 protein has also been shown to play a key role in cancer progression.83 Elevated expression of NUDT5 has been observed in various types of cancer, including breast cancer,84 lung cancer,85 and colon cancer.86 These studies suggest that NUDT5 may be a valuable biomarker for cancer diagnosis and treatment.

In addition to its potential as a drug target, NUDT5 has also been identified as a potential biomarker for several diseases.87-90 NUDT5 has been shown to be downregulated in various diseases, including cancer,91 neurodegenerative diseases,92 and cardiovascular diseases.93 These studies suggest that NUDT5 may be a valuable diagnostic or therapeutic target in diseases where downregulation of the protein has been observed.

The potential drug target for NUDT5 is also under investigation.94 NUDT5 has been shown to interact with several protein kinases, including S/T kinase 3 (STK-3),95 and casein kinase 3 (CK-3).96 Therefore, potential drug targets for NUDT5 may include inhibition of STK-3 and CK-3, which are known to play a role in cell proliferation and survival.97-100

In conclusion, NUDT5 is a unique and highly conserved protein that has been identified as a potential drug target and biomarker. The various functions of NUDT5, including its role in gene regulation and DNA replication, its involvement in cancer progression, and its potential as a biomarker for several diseases make it an attractive target for further investigation. Further studies are needed to fully understand the potential drug target and biomarker properties of NUDT5, and to develop effective treatments for diseases where NUDT5 is involved.

Protein Name: Nudix Hydrolase 5

Functions: Enzyme that can either act as an ADP-sugar pyrophosphatase in absence of diphosphate or catalyze the synthesis of ATP in presence of diphosphate (PubMed:27257257). In absence of diphosphate, hydrolyzes with similar activities various modified nucleoside diphosphates such as ADP-ribose, ADP-mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP (PubMed:10567213, PubMed:10722730, PubMed:19699693, PubMed:21389046, PubMed:17052728). Can also hydrolyze other nucleotide sugars with low activity (PubMed:19699693, PubMed:21389046). In presence of diphosphate, mediates the synthesis of ATP in the nucleus by catalyzing the conversion of ADP-ribose to ATP and ribose 5-phosphate. Nuclear ATP synthesis takes place when dephosphorylated at Thr-45 (PubMed:27257257). Nuclear ATP generation is required for extensive chromatin remodeling events that are energy-consuming (PubMed:27257257). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity)

The "NUDT5 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUDT5 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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