NUDT16L1: A Protein Implicated in Brain Health and Function (G84309)

Target Name: NUDT16L1

NCBI ID: G84309

NUDT16L1

NUDT16L1: A Protein Implicated in Brain Health and Function

NUDT16L1 (SDOS) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the NUDT family of proteins, which are known for their role in intracellular signaling. In particular, NUDT16L1 is involved in the regulation of cellular processes that are important for maintaining brain health and function.

One of the key functions of NUDT16L1 is its role in the regulation of the blood-brain barrier (BBB). The BBB is a specialized barrier that separates the brain from the surrounding bloodstream, and it is designed to protect the brain from harmful substances that could cause damage. However, this barrier is also selective, and it allows certain substances to come into the brain while keeping others out. NUDT16L1 is involved in the regulation of the BBB by promoting the formation of tight junctions between cells in the brain endothelial system (ES).

NUDT16L1 is also involved in the regulation of cell proliferation and differentiation. In the brain, NUDT16L1 is required for the proper formation and maintenance of neuronal cell types, as well as for the regulation of the size and shape of these cells. This is important for the development and maintenance of normal brain function, as well as for the regulation of various neurological disorders.

In addition to its role in cell biology, NUDT16L1 is also thought to be involved in the regulation of inflammation. The brain is a complex and dynamic environment that is constantly exposed to various triggers of inflammation, such as bacteria, viruses, and other harmful substances. NUDT16L1 is involved in the regulation of these inflammatory responses, as well as in the regulation of the immune system more broadly.

Given the involvement of NUDT16L1 in so many important cellular processes, it is a promising target for the development of new treatments for a variety of neurological and psychiatric disorders. For example, NUDT16L1 has been shown to be involved in the development of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, as well as in the regulation of various psychiatric disorders, such as depression and anxiety.

In addition to its potential therapeutic applications, NUDT16L1 is also an important biomarker for the diagnosis and monitoring of various neurological disorders. For example, NUDT16L1 has been shown to be decreased in the brains of individuals with Alzheimer's disease, and this may be an indicator of the disease's severity. Similarly, the levels of NUDT16L1 have been shown to be increased in the brains of individuals with depression, and this may be an indicator of the severity of the disease.

Overall, NUDT16L1 is a protein that is involved in a wide range of important cellular processes in the brain. Its involvement in the regulation of the blood-brain barrier, cell proliferation and differentiation, and inflammation makes it a promising target for the development of new treatments for a variety of neurological and psychiatric disorders. Additionally, its use as a biomarker for the diagnosis and monitoring of these disorders adds to its importance in the field of neurology.

Protein Name: Nudix Hydrolase 16 Like 1

Functions: Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin (PubMed:28241136). In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus (PubMed:28241136). Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs) (PubMed:28241136). Binds U8 snoRNA (PubMed:18820299)

The "NUDT16L1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUDT16L1 comprehensively, including but not limited to:
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