NUDT11: A Potential Drug Target and Biomarker (G55190)

Target Name: NUDT11

NCBI ID: G55190

NUDT11

NUDT11: A Potential Drug Target and Biomarker

Nucleoside diphosphate-linked moiety X (NUDT11) is a protein that plays a crucial role in various cellular processes, including DNA replication, transcription, and repair. It is a key player in the DNA damage response, which is a critical pathway that helps the cell respond to DNA mutations and fidelity checkpoints. NUDT11 has also been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. As a result, it has become an attractive target for drug development.

The NUDT11 protein is a 21-kDa protein that is composed of 11 non-coding exons. It is characterized by a NUDT11 motif, which is a specific DNA-binding motif that is present in various genomic regions. The NUDT11 motif is composed of three domains: a nucleoside diphosphate-binding domain, a G-Crich motif, and a T-box domain.

The NUDT11 protein functions as a nucleoside diphosphate-linked moiety X (NUDT11) enzyme. This enzyme adds a phosphate group to the 3'-end of a diphosphate nucleoside. This reaction is critical for DNA replication, transcription, and repair. In addition, NUDT11 can also act as a kinase, which is a protein that catalyzes the transfer of a phosphate group from a client protein to a regulatory protein. This kinase activity is critical for regulating various cellular processes, including cell growth, differentiation, and apoptosis.

The NUDT11 protein has been implicated in various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, studies have shown that NUDT11 is overexpressed or downregulated in various cancer types, including breast, ovarian, and colorectal cancers. This overexpression or downregulation is associated with poor prognosis and increased disease risk. In addition, NUDT11 has also been implicated in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. The NUDT11 protein has been shown to be overexpressed in the brains of individuals with Alzheimer's disease, and this overexpression is associated with increased neurofibrillary tangles and decreased protein levels of NUDT11.

In addition to its role in diseases, NUDT11 has also been shown to be a potential drug target. The NUDT11 protein can be targeted by small molecules, including inhibitors of the NUDT11 kinase activity. Such inhibitors have been shown to be effective in preclinical studies for treating various diseases, including cancer, neurodegenerative diseases, and developmental disorders. For example, a small molecule inhibitor, MK-8628, has been shown to be effective in preclinical studies for treating neurodegenerative diseases, including Alzheimer's disease.

Another potential drug target for NUDT11 is its role in the DNA damage response. The DNA damage response is a critical pathway that helps the cell respond to DNA mutations and fidelity checkpoints. NUDT11 is involved in the regulation of DNA replication, transcription, and repair, which are critical components of the DNA damage response. Therefore, inhibitors of NUDT11 have been shown to be effective in treating various diseases, including cancer, neurodegenerative diseases, and developmental disorders.

In conclusion, NUDT11 is a protein that plays a crucial role in various cellular processes, including DNA replication, transcription, and repair. Its role in the DNA damage response makes it an attractive target for drug development. The NUDT11 protein can be targeted by small molecules, including inhibitors of the NUDT11 kinase activity. In addition, NUDT11 has also been shown to be involved in the regulation of the DNA damage response, which makes it a potential drug target for treating various diseases, including cancer, neurodegenerative diseases, and developmental disorders. Further research is needed to fully understand the role of NUDT11 in disease and to develop effective treatments.

Protein Name: Nudix Hydrolase 11

Functions: Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate

The "NUDT11 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NUDT11 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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