PDCL3: A Protein Involved in Intracellular Signaling, Inflammation and Stress

Target Name: PDCL3

NCBI ID: G79031

PDCL3

PDCL3: A Protein Involved in Intracellular Signaling, Inflammation and Stress

PDCL3 (Phosducin-like protein 3) is a protein that is expressed in various tissues throughout the body, including the brain, heart, and kidneys. It is a member of the phosducin gene family, which is known for the production of a variety of proteins that play important roles in cellular signaling and signaling pathways.

One of the functions of PDCL3 is its role in intracellular signaling. It is a potent negative regulator of the protein kinase Akt (PKA), which is involved in a wide range of cellular processes, including cell growth, differentiation, and survival. When PKA activity is activated, it causes the phosphorylation of many cellular proteins, including PDCL3. This phosphorylation of PDCL3 can then inhibit its own phosphorylation, and this inhibition can have a positive or negative effect depending on the context.

PDCL3 is also involved in the regulation of cellular processes related to inflammation and stress. It has been shown to play a role in the regulation of the immune response, and it has been shown to contribute to the regulation of inflammation and stress responses.

In addition to its role in intracellular signaling, PDCL3 is also a potential drug target. Its function as a negative regulator of PKA makes it a potential target for small molecules that can inhibit PKA activity. This has led to the development of a number of potential drugs that target PDCL3, including inhibitors of PDCL3's own phosphorylation and inhibitors of PKA activity.

PDCL3 has also been shown to be a potential biomarker for a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. Its role in these diseases, as well as its potential as a drug target, makes it an important area of 鈥嬧?媟esearch for scientists study the underlying mechanisms of these diseases.

In conclusion, PDCL3 is a protein that is involved in a wide range of cellular processes, including intracellular signaling, inflammation, and stress responses. Its function as a negative regulator of PKA makes it a potential target for small molecules, and its potential as a biomarker for a variety of diseases makes it an important area of 鈥嬧?媟esearch for scientists studying these diseases. Further research is needed to fully understand the role of PDCL3 in these processes and to develop effective treatments for these diseases.

Protein Name: Phosducin Like 3

Functions: Acts as a chaperone for the angiogenic VEGF receptor KDR/VEGFR2, increasing its abundance by inhibiting its ubiquitination and degradation (PubMed:23792958, PubMed:26059764). Inhibits the folding activity of the chaperonin-containing T-complex (CCT) which leads to inhibition of cytoskeletal actin folding (PubMed:17429077). Acts as a chaperone during heat shock alongside HSP90 and HSP40/70 chaperone complexes (By similarity). Modulates the activation of caspases during apoptosis (PubMed:15371430)

The "PDCL3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDCL3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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