PCP4: A Protein of Focus for Therapeutic Developments (G5121)

Target Name: PCP4

NCBI ID: G5121

PCP4

PCP4: A Protein of Focus for Therapeutic Developments

Proteolytic enzymes, also known as peptidases, are a group of enzymes that break down other proteins into smaller peptides. These enzymes are essential for many cellular processes, including cell signaling, tissue repair, and inflammation. One of the most well-known proteases is PCP4 (poly (D-Aspartate) 4), a protein that is expressed in many different tissues and cells in the body. PCP4 has been shown to play a role in a variety of cellular processes, including the regulation of cell signaling pathways, cell death, and tissue repair. As a result, PCP4 has become a focus of interest for researchers who are seeking new treatments for a variety of diseases.

In this article, we will explore the PCP4 protein and its potential as a drug target or biomarker. We will discuss the structure and function of PCP4, as well as its role in cellular processes and the potential therapeutic uses for PCP4-based treatments.

Structure and Function

PCP4 is a member of the Aspartate proteases (APC) family, which includes a group of enzymes that use Aspartate as a substrate for their catalytic activity. APC enzymes are involved in the regulation of a wide range of cellular processes, including cell signaling, cell death, and tissue repair.

PCP4 is a 21-kDa protein that is expressed in many different tissues and cells in the body. It is highly conserved, with a calculated pI of 5.6 and a predicted monomeric mass of 34 kDa. PCP4 is synthesized using the same machinery as other proteases , and it is translated from mRNA into a functional protein using the process of translation.

In terms of its structure, PCP4 is a single-chain protein that consists of 194 amino acid residues. It has a characteristic Rossmann-fold that is present in many proteins of the APC family. This fold is responsible for the catalytic activity of the enzyme and is the site of most of the protein's activity.

In terms of its function, PCP4 is involved in a wide range of cellular processes. It has been shown to be involved in the regulation of cell signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and it is a key regulator of many diseases, including cancer.

PCP4 has also been shown to be involved in the regulation of cell death, which is a critical process for maintaining tissue homeostasis and for the regulation of many cellular processes. In addition, PCP4 has been shown to play a role in tissue repair, including the regulation of the healing of wounds and the formation of new tissues.

Potential Therapeutic Uses

PCP4 has the potential to be a drug target or biomarker in a variety of diseases. Its involvement in the regulation of cell signaling pathways, cell death, and tissue repair makes it an attractive target for small molecule inhibitors. In addition, its high conservation and stability make it a good candidate for biomarkers that can be used to monitor disease progression.

One of the most promising PCP4-based treatments is a small molecule inhibitor called Pep19, which is designed to inhibit PCP4's catalytic activity. Pep19 has been shown to be effective in animal models of cancer, including inhibiting the growth of tumors and inhibiting the development of cancer-induced metastases.

Another potential PCP4-based treatment is a monoclonal antibody (mAb) that targets PCP4. The mAb is designed to bind to PCP4 and prevent it from catalyzing the breakdown of other proteins, including cancer-associated proteins. This approach has the potential to be a Highly effective cancer treatment, as it can target tumors without affecting normal cells.

Conclusion

In conclusion, PCP4 is a well-conserved and highly-regulated protein that is involved in a wide range of cellular processes

Protein Name: Purkinje Cell Protein 4

Functions: Functions as a modulator of calcium-binding by calmodulin. Thereby, regulates calmodulin activity and the different processes it controls (PubMed:19106096, PubMed:23204517, PubMed:27876793). For instance, may play a role in neuronal differentiation through activation of calmodulin-dependent kinase signaling pathways (PubMed:21491429)

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