PDE12: A Promising Drug Target and Biomarker for Diseases (G201626)

Target Name: PDE12

NCBI ID: G201626

PDE12

PDE12: A Promising Drug Target and Biomarker for Diseases

PDE12 (2',5'-phosphodiesterase 12 (isoform 1)) is a protein that is expressed in various tissues and cells in the human body. It is a key enzyme in the degradation pathway of cAMP, which is a critical signaling molecule that plays a crucial role in many cellular processes. Mutations in the PDE12 gene have been linked to various diseases, including cardiovascular disease, neurodegenerative diseases, and reproductive disorders. As a result, PDE12 has emerged as a promising drug target and a biomarker for a variety of diseases.

PDE12 is a member of the superfamily of phosphodiesterases, which are a group of enzymes that regulate the breakdown of phosphate groups in biological molecules. These enzymes catalyze the formation of a phosphate esters from the corresponding acids, which allows them to participate in a variety of cellular processes. In the case of PDE12, it is involved in the degradation of cAMP, which is a key signaling molecule that plays a crucial role in many cellular processes.

The PDE12 gene is located on chromosome 11 and encodes a protein that has a molecular weight of approximately 120 kDa. PDE12 is a monomeric protein that consists of a single transmembrane domain and a catalytic active site that is located at the center of the protein. The transmembrane domain is made up of a single amino acid residue and is responsible for the protein's ability to interact with other cellular components. The catalytic active site is the site of the protein's catalytic activity and is made up of multiple amino acids that are involved in the formation of the phosphate esters.

Mutations in the PDE12 gene have been linked to various diseases, including cardiovascular disease, neurodegenerative diseases, and reproductive disorders. For example, mutations in the PDE12 gene have been linked to the development of heart failure, neurodegenerative diseases, and infertility. In addition, mutations in the PDE12 gene have also been linked to the development of certain reproductive disorders, such as male infertility and polycystic ovary syndrome (PCOS).

In addition to its role in the degradation of cAMP, PDE12 has also been shown to play a role in the regulation of other signaling pathways. For example, studies have shown that PDE12 is involved in the regulation of cell adhesion, which is the process by which cells stick together and form tissues. In addition, PDE12 has also been shown to be involved in the regulation of cell proliferation, which is the process by which cells grow and divide.

Given the importance of PDE12 in the regulation of cellular processes, it is a promising drug target and a biomarker for a variety of diseases. Researchers are currently working to develop new compounds that can selectively target PDE12 and inhibit its catalytic activity. These compounds have the potential to be used to treat a variety of diseases, including cardiovascular disease, neurodegenerative diseases, and reproductive disorders.

In conclusion, PDE12 is a protein that is expressed in various tissues and cells in the human body and is involved in the degradation of cAMP. Mutations in the PDE12 gene have been linked to various diseases, including cardiovascular disease, neurodegenerative diseases, and reproductive disorders. As a result, PDE12 has emerged as a promising drug target and a biomarker for a variety of diseases. While further research is needed to fully understand the role of PDE12 in the regulation of cellular processes, studies are currently underway to develop new compounds that can selectively target PDE12 and inhibit its catalytic activity.

Protein Name: Phosphodiesterase 12

Functions: Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system. Degrades triphosphorylated 2-5A to produce AMP and ATP (PubMed:26055709). Also cleaves 3',5'-phosphodiester bond of oligoadenylates (PubMed:21666256, PubMed:30389976, PubMed:26055709). Plays a role as a negative regulator of the 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme increases cellular 2-5A levels and decreases viral replication in cultured small-airway epithelial cells and Hela cells (PubMed:26055709)

The "PDE12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about PDE12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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