PDCD2: Structure, Function, Drug Targets and Clinical Applications

Target Name: PDCD2

NCBI ID: G5134

PDCD2

PDCD2: Structure, Function, Drug Targets and Clinical Applications

PDCD2 (Zinc finger MYND domain-containing protein 7) is a protein that is expressed in almost all eukaryotic cells and plays an important role in a variety of diseases. Its functions include participating in important life processes such as cell signaling, cell cycle regulation, and apoptosis. In addition, PDCD2 also interacts with many drug targets and is therefore considered a potential drug target or biomarker. This article will introduce in detail the structure, function, drug targets and role of PDCD2 in diseases, and explore its clinical application prospects.

1. Structure

PDCD2 is a zinc finger transcription factor that belongs to the MYND family. The MYND family is a class of transcription factors characterized by a MYND domain, which is a binding site for transcription factors that can bind to specific sequences in DNA. The MYND domain of PDCD2 contains a zinc finger structure that can bind to specific sequences in DNA, thereby promoting the transcription and expression of PDCD2.

The molecular structure of PDCD2 is shown in Figure 1. PDCD2 consists of 119 amino acids, including a zinc finger structure, an EF-1 region, an EF-2 region and a tail structure. The zinc finger structure is one of the most important structures in the PDCD2 molecule. It consists of a special chemical group that can bind to specific sequences in DNA. The zinc finger structure is composed of the C-terminal region of PDCD2 and includes an 伪-helix, a 尾-sheet and a twisted structure.

2. Function

PDCD2 plays an important role in a variety of biological processes. In cell signaling, PDCD2 can participate in the signal transduction process. For example, PDCD2 can bind to CREB and thereby participate in the regulation of cell fate. In cell cycle regulation, PDCD2 can participate in the control of cell cycle. For example, PDCD2 can bind to CDK4 and thereby participate in cell cycle progression. In addition, PDCD2 can also participate in apoptosis and play an important role in the process of cell death.

PDCD2 can also interact with many drug targets. For example, PDCD2 can interact with antipsychotics and antitumor drugs, thereby affecting the efficacy and toxicity of the drugs. In addition, PDCD2 can also interact with certain disease-related genes, thereby participating in the occurrence and development of diseases. For example, PDCD2 can interact with depression-related genes and thus participate in the occurrence of depression.

3. Drug Targets

PDCD2 is an important drug target and interacts with many drugs. For example, antipsychotics and antidepressants can act on PDCD2, thereby improving their efficacy and reducing their toxicity. In addition, PDCD2 can also be used as a tumor target. For example, PDCD2-positive tumors are sensitive to capecitabine treatment.

4. Clinical Application Prospects

PDCD2 is an important protein that can be studied as a drug target or biomarker. For example, research on antipsychotics and antineoplastic drugs could focus on the role of PDCD2 and its interactions with drugs. In addition, the role of PDCD2 in tumors and the relationship between PDCD2 and tumors can also be studied.

PDCD2 is an important protein with multiple functions. PDCD2 can be studied as a drug target or biomarker, providing new ideas for disease treatment.

Protein Name: Programmed Cell Death 2

Functions: May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation

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•   general information;
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•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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