MAPK6: A Key Regulator of Cell Signaling and Metabolism (G5597)

Target Name: MAPK6

NCBI ID: G5597

MAPK6

MAPK6: A Key Regulator of Cell Signaling and Metabolism

MAPK6, also known as protein kinase (MAPK6), is a protein that plays a crucial role in cell signaling and metabolism. It is a key regulator of the mitogen-activated protein (MAP) kinase (MAPK) signaling pathway, which is involved in Various cellular processes such as cell growth, differentiation, and inflammation.

MAPK6 is a 21-kDa protein that is expressed in various tissues and cell types. It is highly conserved and has a similar structure to other MAPKs, such as MAPK1, MAPK2, and MAPK3. The protein is composed of a catalytic domain, a carboxy -terminal domain, and a unique N-terminal domain.

The MAPK6 gene is located on chromosome 18q and has been implicated in various cellular processes, including cell proliferation, differentiation, and survival. Studies have shown that MAPK6 is involved in the regulation of cell cycle progression, cell adhesion, and cell survival.

One of the key functions of MAPK6 is its role in the regulation of MAPK signaling. MAPK6 functions as a negative regulator of MAPK, which means that it reduces the activity of MAPK and prevents it from activating the downstream targets of the MAPK signaling pathway. This The interaction between MAPK6 and MAPK is critical for the regulation of cellular processes such as cell growth, differentiation, and survival.

MAPK6 has also been shown to play a role in the regulation of inflammation. Studies have shown that MAPK6 is involved in the regulation of the production of pro-inflammatory cytokines, such as TNF-伪, IL-1尾, and IL-6. This The interaction between MAPK6 and inflammation is critical for the regulation of inflammatory responses and the regulation of tissue repair.

In addition to its role in cell signaling and inflammation, MAPK6 has also been shown to be involved in the regulation of cellular processes such as cell adhesion and the regulation of the cytoskeleton. MAPK6 is a key regulator of the formation of the actin filament, which is a protein structure that is involved in cell adhesion and the regulation of cell migration.

MAPK6 has also been shown to be involved in the regulation of DNA replication and cell cycle progression. Studies have shown that MAPK6 is involved in the regulation of DNA replication, which is critical for the regulation of gene expression and cell cycle progression.

In conclusion, MAPK6 is a protein that plays a crucial role in cell signaling and metabolism. It is a key regulator of the MAPK signaling pathway and is involved in the regulation of cell cycle progression, cell adhesion, inflammation, and DNA replication. As a As a result, MAPK6 is a potential drug target and a biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Protein Name: Mitogen-activated Protein Kinase 6

Functions: Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)

The "MAPK6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAPK6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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