MARCHF4: A Potential Drug Target and Biomarker for Membrane-associated Ring-CH Proteins

Target Name: MARCHF4

NCBI ID: G57574

MARCHF4

MARCHF4: A Potential Drug Target and Biomarker for Membrane-associated Ring-CH Proteins

Membrane-associated ring-CH proteins (MARCs) are a family of transmembrane proteins that play a crucial role in various cellular processes. These proteins are involved in various signaling pathways, including intracellular signaling, cell signaling, and cell-cell communication. MARCs are highly conserved, with similar structures and functions across different species. One of the most well-known MARCs is MARCHF4, which is a protein that is expressed in various tissues and cells, including heart, brain, and cancer cells. In this article, we will discuss the potential drug target and biomarker properties of MARCHF4.

Potential Drug Target

MARCHF4 is a protein that is involved in various signaling pathways, including the TGF-β pathway. This pathway is involved in cell growth, differentiation, and survival. MARCs, including MARCHF4, are known to be involved in the regulation of TGF-β signaling. This can lead to the development of various diseases, including cancer. Therefore, targeting MARCs, including MARCHF4, is a promising strategy for the development of new drugs for various diseases.

MARCHF4 has been shown to play a role in the regulation of TGF-β signaling in various contexts. For instance, studies have shown that MARCHF4 can inhibit the activity of the TGF-β receptor, leading to the inhibition of TGF-β signaling. This has been shown to be a potential therapeutic approach for the treatment of various diseases, including cancer.

Biomarker

MARCHF4 is also a potential biomarker for various diseases. Its expression has been shown to be elevated in various diseases, including cancer. This increased expression of MARCHF4 has been shown to be associated with the development of cancer. Therefore, MARCHF4 can be used as a potential biomarker for cancer diagnosis and treatment.

Expression of MARCHF4

MARCHF4 is a protein that is expressed in various tissues and cells, including heart, brain, and cancer cells. It is primarily expressed in the cytoplasm and is involved in various signaling pathways, including the TGF-β pathway. MARCs, including MARCHF4, are known to be involved in the regulation of TGF-β signaling.

Structure

The structure of MARCHF4 is well conserved across different species. It has a unique catalytic domain that is involved in the regulation of TGF-β signaling. The catalytic domain is known to be involved in the regulation of the activity of the TGF-β receptor, leading to the inhibition of TGF-β signaling.

Function

MARCHF4 is involved in various signaling pathways, including the TGF-β pathway. This pathway is involved in cell growth, differentiation, and survival. MARCs, including MARCHF4, are known to be involved in the regulation of TGF-β signaling. This can lead to the development of various diseases, including cancer. Therefore, targeting MARCs, including MARCHF4, is a promising strategy for the development of new drugs for various diseases.

Conclusion

MARCHF4 is a protein that is involved in various signaling pathways, including the TGF-β pathway. It has been shown to play a role in the regulation of TGF-β signaling in various contexts. Its expression is elevated in various diseases, including cancer. Therefore, targeting MARCs, including MARCHF4, is a promising strategy for the development of new drugs for various diseases. Further studies are needed to fully understand the potential drug target and biomarker properties of MARCHF4.

Protein Name: Membrane Associated Ring-CH-type Finger 4

Functions: E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates

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•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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