MARCHF2: A Potential Drug Target and Biomarker for Membrane-Associated Ring Finger Proteins

Target Name: MARCHF2

NCBI ID: G51257

MARCHF2

MARCHF2: A Potential Drug Target and Biomarker for Membrane-Associated Ring Finger Proteins

Membrane-associated ring finger (MAR) proteins are a family of non-coding RNAs that play a crucial role in various cellular processes. These proteins are characterized by a characteristic domain that includes a nucleotide-rich loop and a transmembrane region. MARs are involved in various cellular processes, including cell signaling, protein-protein interactions, and transcriptional regulation. There are several MARs that have been identified, and some of them have potential as drug targets or biomarkers. In this article, we will focus on MARCHF2, a member of the MAR family that has been shown to have various functions in the cell.

The MARCHF2 Protein

MARCHF2 is a 21-kDa protein that is expressed in various tissues, including brain, heart, and muscle. It is localized to the endoplasmic reticulum (ER) and nuclear envelope (NE), and it is predominantly expressed in the cytoplasm. MARCHF2 is a transcription factor that can interact with various DNA-binding sites. It has been shown to play a role in regulating gene expression, including the expression of genes involved in cell signaling pathways, cell cycle progression, and apoptosis.

MARCHF2 has been shown to interact with several protein partners, including the transcription factor p53. p53 is a well-known protein that plays a critical role in regulating gene expression and cell survival. MARCHF2 has been shown to interact with p53 and to play a role in the regulation of p53-mediated gene expression.

MARCHF2 has also been shown to interact with the protein kinase A尾4. A尾4 is a protein that is involved in the regulation of cellular processes, including cell signaling and neurodegeneration. MARCHF2 has been shown to interact with A尾4 and to play a role in the regulation of A尾4-mediated gene expression.

MARCHF2 has also been shown to interact with the protein S100. S100 is a protein that is involved in the regulation of cellular processes, including cell signaling and neurotransmission. MARCHF2 has been shown to interact with S100 and to play a role in the regulation of S100-mediated gene expression.

MARCHF2 as a Drug Target

MARCHF2 has been shown to have various functions in the cell, including the regulation of cell signaling pathways, cell cycle progression, and apoptosis. As a result, MARCHF2 is a potential drug target. Several studies have shown that inhibiting the activity of MARCHF2 can lead to the inhibition of various cellular processes, including cell signaling, cell cycle progression, and apoptosis.

One of the potential strategies for targeting MARCHF2 is to inhibit the activity of its downstream targets, such as p53, A尾4, and S100. These molecules have been shown to play a critical role in the regulation of various cellular processes, including cell signaling, cell cycle progression, and neurodegeneration.

Another potential strategy for targeting MARCHF2 is to inhibit its synthesis or degradation. MARCHF2 is a nuclear-resident protein, and its synthesis and degradation are regulated by various factors, including the levels of endogenous factors and factors derived from the cytoplasm.

MARCHF2 as a Biomarker

MARCHF2 has also been shown to serve as a biomarker for various diseases, including neurodegenerative diseases. In neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, the accumulation of misfolded proteins, including MARs, is thought to contribute to the development and progression of the disease.

MARCHF2 has been shown to accumulate in the brains of individuals with Alzheimer's disease and to contribute to the development of neuropathological changes in these individuals. Similarly, MARCHF2 has

Protein Name: Membrane Associated Ring-CH-type Finger 2

Functions: E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:14722266, PubMed:16428329). Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR (PubMed:23818989). Ubiquitinates and therefore mediates the degradation of DLG1 (PubMed:17980554). Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3 (PubMed:31142615). Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteosomal degradation (PubMed:32935379). May be involved in endosomal trafficking through interaction with STX6 (PubMed:15689499)

The "MARCHF2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MARCHF2 comprehensively, including but not limited to:
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•   the target screening and validation;
•   expression level;
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•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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