MAPRE1: A Potential Drug Target Or Biomarker for Diseases (G22919)

Target Name: MAPRE1

NCBI ID: G22919

MAPRE1

MAPRE1: A Potential Drug Target Or Biomarker for Diseases

MAPRE1 (MGC129946) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a member of the Maxwell family of transcription factors, which plays a crucial role in regulating gene expression and cell function.

MAPRE1 is known for its ability to interact with the transcription factor NF-kappa-B, which is a known regulator of inflammation, cancer, and other diseases. This interaction between MAPRE1 and NF-kappa-B has led to the hypothesis that MAPRE1 may be a drug target or biomarker for various diseases.

One of the reasons for this hypothesis is that MAPRE1 has been shown to be involved in the regulation of inflammation and immune responses. It has been shown to play a role in the development of neuroinflammatory diseases, such as multiple sclerosis and rheumatoid arthritis. Additionally, MAPRE1 has been shown to be involved in the regulation of cancer cell growth and survival, which could make it a potential biomarker for cancer.

Another potential mechanism by which MAPRE1 may be involved in disease is by its role in the regulation of cell death.MAPRE1 has been shown to play a role in the regulation of cell apoptosis, which is the process by which cells die naturally. This suggests that it may be involved in the development of diseases that are characterized by the apoptosis of cells, such as neurodegenerative diseases.

MAPRE1 is also known for its role in the regulation of stem cell proliferation and differentiation. It has been shown to play a role in the regulation of the stem cell factor G-CSF, which is a protein that promotes the proliferation and differentiation of stem cells . This suggests that MAPRE1 may be involved in the development of diseases that are characterized by the overgrowth or dysfunction of stem cells, such as cancer.

In conclusion, MAPRE1 is a protein that has been shown to play a role in the regulation of various physiological processes in the body, including inflammation, immune responses, cancer cell growth and survival, and cell apoptosis. Its involvement in these processes makes it a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the role of MAPRE1 in disease and to develop effective treatments.

Protein Name: Microtubule Associated Protein RP/EB Family Member 1

Functions: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity)

The "MAPRE1 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAPRE1 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets