Target Name: WDR48
NCBI ID: G57599
Review Report on WDR48 Target / Biomarker Content of Review Report on WDR48 Target / Biomarker
WDR48
Other Name(s): P80 | WD repeat domain 48, transcript variant 1 | KIAA1449 | WD repeat-containing protein 48 | p80 | testicular tissue protein Li 224 | USP1 associated factor 1 | WD repeat domain 48 | WD repeat-containing protein 48 (isoform 1) | USP1-associated factor 1 | WDR48_HUMAN | UAF1 | WD repeat endosomal protein | WDR48 variant 1 | DKFZp686G1794 | SPG60 | Bun62

WDR48: A Non-Code RNA Molecule in Cell Adhesion, Migration and Pluripotency

WDR48 (Wnt-derived receptor 48) is a non-coding RNA molecule that has been shown to play a role in various cellular processes, including cell adhesion, migration, and pluripotency. WDR48 has also been shown to be involved in the development and progression of various diseases, including cancer. As a result, WDR48 has gained significant interest as a potential drug target or biomarker.

The Wnt signaling pathway is a well-established mechanism that regulates cell development and has been implicated in the development of many diseases, including cancer. Wnt signaling involves the interaction between the protein Wnt and its receptor, WDR48. Wnt is a transmembrane glycoprotein that is involved in the development and maintenance of the neural tube, which forms the early embryo. Wnt signaling is important for the development and maintenance of tissues and organs, including neural cells, and is often disrupted in diseases such as cancer.

WDR48 is a key component of the Wnt signaling pathway and has been shown to play a role in the regulation of various cellular processes. WDR48 is a non-coding RNA molecule that is derived from the Wnt receptor. It is expressed in a variety of tissues and cells and has been shown to be involved in the regulation of cell adhesion, migration, and pluripotency.

One of the most significant functions of WDR48 is its role in cell adhesion. WDR48 has been shown to be involved in the regulation of tight junctions, which are a type of cell-cell adhesion that helps to maintain the integrity of tissues. tight junctions are critical for the regulation of various cellular processes, including cell signaling, and are often disrupted in diseases such as cancer. As a result, WDR48 has been shown to be a potential drug target or biomarker for diseases that are characterized by the disruption of tight junctions.

WDR48 is also involved in the regulation of cell migration. Cell migration is a critical process that enables cells to move and divide in order to perform their proper functions in the body. WDR48 has been shown to be involved in the regulation of cell migration and has been shown to play a role in the development of various diseases, including cancer. As a result, WDR48 has been shown to be a potential drug target or biomarker for diseases that are characterized by the disruption of cell migration.

WDR48 is also involved in the regulation of pluripotency, which is the ability of stem cells to develop into any type of cell in the body. WDR48 has been shown to be involved in the regulation of pluripotency and has been shown to play a role in the development of various diseases, including cancer. As a result, WDR48 has been shown to be a potential drug target or biomarker for diseases that are characterized by the disruption of stem cell pluripotency.

In conclusion, WDR48 is a non-coding RNA molecule that has been shown to play a role in various cellular processes, including cell adhesion, migration, and pluripotency. WDR48 is derived from the Wnt receptor and has been shown to be involved in the regulation of cell adhesion, migration, and pluripotency. As a result, WDR48 has gained significant interest as a potential drug target or biomarker for diseases that are characterized by the disruption of these processes. Further research is needed to fully understand the role of WDR48 in the development and progression of various diseases.

Protein Name: WD Repeat Domain 48

Functions: Regulator of deubiquitinating complexes, which acts as a strong activator of USP1, USP12 and USP46 (PubMed:18082604, PubMed:19075014, PubMed:31253762, PubMed:26388029). Enhances the USP1-mediated deubiquitination of FANCD2; USP1 being almost inactive by itself (PubMed:18082604, PubMed:31253762). Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate (PubMed:19075014, PubMed:27373336). Also activates deubiquitinating activity of complexes containing USP12 (PubMed:19075014, PubMed:27650958, PubMed:27373336). In complex with USP12, acts as a potential tumor suppressor by positively regulating PHLPP1 stability (PubMed:24145035). Docks at the distal end of the USP12 fingers domain and induces a cascade of structural changes leading to the activation of the enzyme (PubMed:27650958, PubMed:27373336). Together with RAD51AP1, promotes DNA repair by stimulating RAD51-mediated homologous recombination (PubMed:27463890, PubMed:27239033, PubMed:32350107). Binds single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) (PubMed:27239033, PubMed:31253762, PubMed:32350107). DNA-binding is required both for USP1-mediated deubiquitination of FANCD2 and stimulation of RAD51-mediated homologous recombination: both WDR48/UAF1 and RAD51AP1 have coordinated role in DNA-binding during these processes (PubMed:31253762, PubMed:32350107). Together with ATAD5 and by regulating USP1 activity, has a role in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:20147293). Together with ATAD5, has a role in recruiting RAD51 to stalled forks during replication stress (PubMed:31844045)

The "WDR48 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about WDR48 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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