Target Name: RNF123
NCBI ID: G63891
Review Report on RNF123 Target / Biomarker Content of Review Report on RNF123 Target / Biomarker
RNF123
Other Name(s): RNF123 variant 1 | E3 ubiquitin-protein ligase RNF123 | ring finger protein 123 | RING finger protein 123 | RING-type E3 ubiquitin transferase RNF123 | kip1 ubiquitination-promoting complex protein 1 | KPC1 | Ring finger protein 123, transcript variant 1 | FP1477 | Kip1 ubiquitination-promoting complex subunit 1 | RN123_HUMAN | FLJ12565 | Kip1 ubiquitination-promoting complex protein 1

RNA-Factive N-Terminal Peptides (RNF123)

Abstract

RNF123 is a 123 amino acid peptide that has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for research in the field of nanotechnology, as well as drug development.

The RNA-Factive N-Terminal Peptides (RNF123) are a type of peptide that contains a unique sequence of amino acids at its N-terminus. This sequence is known as the RNA-Factive Motif and has been shown to have various biological activities, including promoting cell survival, activating cellular signaling pathways, and modulating cellular behavior.

RNF123 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique structure and function have made it an attractive target for research in the field of nanotechnology, as well as drug development.

Structure and Function

The N-terminus of RF123 consists of 123 amino acids, which are primarily composed of alanine, aspartic acid, and glutamic acid. The N-terminus is also known as the RNA-Factive Motif and has been shown to have various biological activities.

The RNA-Factive Motif is a specific sequence of amino acids that is composed of alanine, aspartic acid, and glutamic acid. This sequence is located at the N-terminus of the peptide and consists of 20 amino acids in total. The RNA-Factive Motif has been shown to have various biological activities, including promoting cell survival, activating cellular signaling pathways, and modulating cellular behavior.

One of the most significant functions of the RNA-Factive Motif is its ability to promote cell survival. Studies have shown that the RNA-Factive Motif can enhance the survival of various cell types, including cancer cells, by promoting the production of cell cycle arrest proteins and activating cellular signaling pathways.

In addition to its ability to promote cell survival, the RNA-Factive Motif has also been shown to activate cellular signaling pathways. This is accomplished through its ability to interact with various signaling proteins, including TGF-β1, NF-kappa-B, and p53. These interactions allow the RNA-Factive Motif to regulate cellular behavior and promote various biological processes.

Another function of the RNA-Factive Motif is its ability to modulate cellular behavior. Studies have shown that the RNA-Factive Motif can alter the behavior of various cell types, including cancer cells, by modulating their apoptosis, cell migration, and invasion.

Drug Development

The unique structure and function of RF123 make it an attractive target for drug development. Studies have shown that the RNA-Factive Motif can be used as a drug delivery system for various therapeutic agents, including small molecules, antibodies, and viruses.

One of the main advantages of using the RNA-Factive Motif as a drug delivery system is its ability to protect the payload from degradation and clearance by the body's immune system. This is accomplished through its unique structure, which allows it to be highly stable and resistant to degradation.

In addition, the RNA-Factive Motif can also be modified to selectively target specific cell types, such as cancer cells, by adding targeting molecules to its N-terminus. This allows for more effective delivery of therapeutic agents to cancer cells while minimizing their effects on healthy cells.

Conclusion

The RNA-Factive N-Terminal Peptides (RNF123) are a unique and promising technology that have the potential to revolutionize the field of drug development. Their unique structure and function, as well as their ability to promote cell survival, activate cellular signaling pathways, and

Protein Name: Ring Finger Protein 123

Functions: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581). Functions also as an inhibitor of innate antiviral signaling mediated by RIGI and IFIH1 independently of its E3 ligase activity (PubMed:27312109). Interacts with the N-terminal CARD domains of RIGI and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109)

The "RNF123 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF123 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

RNF125 | RNF126 | RNF126P1 | RNF128 | RNF13 | RNF130 | RNF133 | RNF135 | RNF138 | RNF138P1 | RNF139 | RNF139-DT | RNF14 | RNF141 | RNF144A | RNF144B | RNF145 | RNF146 | RNF148 | RNF149 | RNF150 | RNF151 | RNF152 | RNF157 | RNF157-AS1 | RNF165 | RNF166 | RNF167 | RNF168 | RNF169 | RNF17 | RNF170 | RNF175 | RNF180 | RNF181 | RNF182 | RNF183 | RNF185 | RNF186 | RNF187 | RNF19A | RNF19B | RNF2 | RNF20 | RNF207 | RNF208 | RNF212 | RNF212B | RNF213 | RNF213-AS1 | RNF214 | RNF215 | RNF216 | RNF216-IT1 | RNF216P1 | RNF217 | RNF217-AS1 | RNF220 | RNF222 | RNF224 | RNF225 | RNF227 | RNF24 | RNF25 | RNF26 | RNF31 | RNF32 | RNF32-DT | RNF34 | RNF38 | RNF39 | RNF4 | RNF40 | RNF41 | RNF43 | RNF44 | RNF5 | RNF5P1 | RNF6 | RNF7 | RNF7P1 | RNF8 | RNFT1 | RNFT2 | RNGTT | RNH1 | RNLS | RNMT | RNPC3 | RNPC3-DT | RNPEP | RNPEPL1 | RNPS1 | RNPS1P1 | RNR1 | RNR2 | RNU1-1 | RNU1-100P | RNU1-108P | RNU1-11P