TMEM168 (TM168_HUMAN): A Potential Drug Target and Biomarker (G64418)

Target Name: TMEM168

NCBI ID: G64418

TMEM168

TMEM168 (TM168_HUMAN): A Potential Drug Target and Biomarker

Introduction

TMEM168 (Tissue Membrane receptor subtype 168) is a protein located on the cell membrane and belongs to the transmembrane protein family. It plays an important role in various physiological processes such as cell signaling, cell adhesion, cell migration, cell differentiation, and cell cycle regulation. In recent years, researchers have gradually conducted in-depth research on TMEM168 and discovered its potential value in drug development and disease treatment. This article will discuss the biological properties, pharmacological significance, clinical application prospects and other aspects of TMEM168 to provide certain theoretical support for the research and application of TMEM168.

1. Biological properties of TMEM168

TMEM168 is a transmembrane protein with 75 amino acids and a molecular weight of approximately 50 kDa. TMEM168 has a rich expression pattern in the cell membrane and is mainly expressed on the outside of the cell membrane. In addition, TMEM168 has multiple functions in cells, such as cell adhesion, cell migration, cell differentiation, cell cycle regulation, etc. These features make TMEM168 a very attractive drug target.

2. Pharmacological significance of TMEM168

1. Drug discovery and screening

As a new drug target, TMEM168 has broad application prospects. By screening specific TMEM168-specific inhibitors, it is expected to provide new ideas for drug development. In addition, TMEM168, as a protein ubiquitously present in a variety of organisms, also provides the possibility of screening drugs with universal properties.

2. Drug action mechanism

TMEM168 plays a key role in the drug's action. By blocking TMEM168, cell adhesion, migration and proliferation can be inhibited, thereby achieving therapeutic purposes. At the same time, TMEM168 also plays an important role in cell cycle regulation, controlling cell growth and division by regulating the cell cycle. These pharmacological implications make TMEM168 a drug target with broad application prospects.

3. Clinical application prospects

TMEM168 has broad application prospects in drug development and disease treatment. By developing specific inhibitors, it is expected to provide new therapeutic methods for the treatment of various diseases. In addition, TMEM168 provides an important theoretical basis for drug research and development in drug screening and mechanism of action research, and is expected to bring more good news to human health.

3. Clinical application prospects of TMEM168

1. Treat cancer

TMEM168 plays an important role in various cancers, such as breast cancer, lung cancer, prostate cancer, etc. By blocking TMEM168, it is expected to provide new treatment options for cancer patients. Currently, researchers are conducting research on TMEM168 targeted therapy, aiming to bring more effective treatments to cancer patients.

2. Treat cardiovascular disease

TMEM168 also plays an important role in cardiovascular disease. By regulating the function of TMEM168, the metabolic and contractile functions of cardiomyocytes can be improved, thereby reducing the risk of cardiovascular disease. Currently, researchers are conducting research on TMEM168 targeted treatment of cardiovascular diseases to provide new treatment options for patients with cardiovascular diseases.

3. Treat neurodegenerative diseases

TMEM168 also plays an important role in neurodegenerative diseases. By regulating the function of TMEM168, the living environment of nerve cells can be improved, thereby slowing the development of neurodegenerative diseases. Currently, researchers are conducting research on TMEM168 targeted treatment of neurodegenerative diseases to provide new treatment options for patients with neurodegenerative diseases.

4. Conclusion

As a protein with broad application prospects, TMEM168 plays an important role in drug development and disease treatment. By developing specific inhibitors, it is expected to provide new therapeutic methods for the treatment of various diseases. TMEM168 has broad pharmacological significance and clinical application prospects in breast cancer, lung cancer, prostate cancer, cardiovascular diseases and neurodegenerative diseases, and is expected to bring more good news to human health.

Protein Name: Transmembrane Protein 168

Functions: Plays a key role in maintaining the cardiac electrical stability by modulating cell surface expression of SCN5A (PubMed:32175648). May play a role in the modulation of anxiety behavior by regulating GABAergic neuronal system in the nucleus accumbens (By similarity)

The "TMEM168 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM168 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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