MAPK12: A Protein Target for Cancer and Other Diseases (G6300)

Target Name: MAPK12

NCBI ID: G6300

MAPK12

MAPK12: A Protein Target for Cancer and Other Diseases

MAPK12 (SAPK3) is a protein that is expressed in various tissues of the body, including the brain, heart, and muscle. It is a member of the MAPK1 family of serine/threonine kinases, which are involved in a variety of cellular processes, including cell signaling, cell division, and inflammation. One of the functions of MAPK12 is to regulate the activity of other proteins, including the protein kinase 3 (MAPK3), which is a key enzyme involved in cell signaling.

MAPK12 has been shown to play a role in a variety of biological processes, including the regulation of neural plasticity, the development and progression of cancer, and the regulation of inflammation. It is also thought to be involved in the regulation of cellular metabolism and the maintenance of cellular homeostasis.

Due to its involvement in a number of important cellular processes, MAPK12 has been identified as a potential drug target. Researchers are currently working to develop small molecules that can inhibit the activity of MAPK12 and prevent it from causing harm. These small molecules have the potential to be used to treat a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

In addition to its potential as a drug target, MAPK12 is also a potential biomarker. The activity of MAPK12 has been shown to be altered in a variety of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. By measuring the activity of MAPK12, researchers may be able to diagnose and monitor these conditions.

Overall, MAPK12 is a protein that is widely expressed in various tissues of the body and is involved in a variety of important cellular processes. Its potential as a drug target and biomarker make it an attractive target for research into the development of new treatments for a variety of diseases.

Protein Name: Mitogen-activated Protein Kinase 12

Functions: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in myoblast differentiation and also in the down-regulation of cyclin D1 in response to hypoxia in adrenal cells suggesting MAPK12 may inhibit cell proliferation while promoting differentiation. Phosphorylates DLG1. Following osmotic shock, MAPK12 in the cell nucleus increases its association with nuclear DLG1, thereby causing dissociation of DLG1-SFPQ complexes. This function is independent of its catalytic activity and could affect mRNA processing and/or gene transcription to aid cell adaptation to osmolarity changes in the environment. Regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage and G2 arrest after gamma-radiation exposure. MAPK12 is involved in the regulation of SLC2A1 expression and basal glucose uptake in L6 myotubes; and negatively regulates SLC2A4 expression and contraction-mediated glucose uptake in adult skeletal muscle. C-Jun (JUN) phosphorylation is stimulated by MAPK14 and inhibited by MAPK12, leading to a distinct AP-1 regulation. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration

The "MAPK12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAPK12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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