MAPK10: A Protein Involved in Cellular Signaling and Disease (G5602)

Target Name: MAPK10

NCBI ID: G5602

MAPK10

MAPK10: A Protein Involved in Cellular Signaling and Disease

MAPK10, also known as Mitogen-Activated Protein Kinase 10 (MAPK10), is a protein that plays a crucial role in cellular signaling. It is a member of the MAPK family, which includes several related proteins that regulate various cellular processes, including cell growth , differentiation, and inflammation. MAPK10 is one of the kinases in this family and is involved in the regulation of cellular responses to various stimuli, including growth factors and cytokines.

MAPK10 is a protein that is expressed in many different cell types, including neurons, muscle cells, and immune cells. It is involved in a wide range of cellular processes, including cell growth, differentiation, and apoptosis (programmed cell death). MAPK10 is also involved in the regulation of cellular signaling pathways, including the TGF-β pathway, which is involved in cell growth and differentiation.

One of the functions of MAPK10 is to regulate the activity of several transcription factors, including NF-kappa-B, AP-1, and STAT3. These transcription factors are responsible for regulating the expression of genes that are involved in various cellular processes, including cell growth , differentiation, and inflammation. By regulating the activity of these transcription factors, MAPK10 helps to ensure that cells respond to various stimuli in an appropriate and timely manner.

MAPK10 is also involved in the regulation of cellular signaling pathways that are involved in cell death and stress. It is involved in the regulation of cell apoptosis (programmed cell death), which is a natural process that helps to remove damaged or unnecessary cells from the body. MAPK10 is also involved in the regulation of cellular stress responses, which are necessary for the survival of cells in the face of various stressors, including those that are caused by environmental toxins or stressors.

MAPK10 is also involved in the regulation of cellular signaling pathways that are involved in inflammation and immune responses. It is involved in the regulation of the production and activation of immune cells, including T cells and macrophages. production of pro-inflammatory cytokines, which are involved in the regulation of inflammation.

Despite its involvement in a wide range of cellular processes, MAPK10 is a relatively small protein. It has a molecular weight of approximately 180 kDa and is expressed in a variety of different cell types. It is found in a variety of cellular organelles, including the cytoplasm and the endoplasmic reticulum.

MAPK10 is a protein that is being targeted by researchers as a potential drug target for a variety of diseases. For example, MAPK10 has been shown to be involved in the regulation of cellular processes that are involved in cancer, including the regulation of cell growth, apoptosis, and angiogenesis (the formation of new blood vessels). It is also involved in the regulation of cellular signaling pathways that are involved in inflammation and immune responses, which could be useful for the treatment of autoimmune diseases and other inflammatory conditions.

In addition to its potential clinical applications, MAPK10 is also an attractive biomarker for the study of various diseases. For example, it is often used as a marker for the treatment of cancer, as it is often expressed in higher levels in cancer cells compared to healthy cells. It is also used as a marker for the assessment of the efficacy of certain drugs, as the inhibition of MAPK10 activity has been shown to be a potential therapeutic approach for the treatment of various diseases.

Overall, MAPK10 is a protein that plays a crucial role in cellular signaling and is involved in a wide range of cellular processes. It is a potential drug target for a variety of diseases and is also an attractive biomarker for the study of these diseases. Further research is needed to fully understand the functions of MAPK10 and its potential as a therapeutic approach.

Protein Name: Mitogen-activated Protein Kinase 10

Functions: Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as pro-inflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692). Phosphorylates JUND and this phosphorylation is inhibited in the presence of MEN1 (PubMed:22327296)

The "MAPK10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about MAPK10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets