KRTAP4-6: A Potential Drug Target and Biomarker (G81871)

Target Name: KRTAP4-6

NCBI ID: G81871

KRTAP4-6

KRTAP4-6: A Potential Drug Target and Biomarker

Keratin associated protein 4-15 (KRTAP4-6) is a protein that is expressed in a variety of tissues, including hair, nails, and skin. It is a member of the keratin gene family, which encodes the proteins that make up the fundamental structure of hair and nails. KRTAP4-6 has been shown to play a role in the regulation of cell growth and differentiation, and it is potential drug target and biomarker.

The hair and nail growth cycle is a complex process that involves the regulation of many different proteins. KRTAP4-6 is one of the proteins that is involved in this regulation. During the growth cycle, KRTAP4-6 is expressed in the stem cells of the hair and nail follicles, and it plays a role in the development and differentiation of these cells into the hair and nail tips.

In addition to its role in hair and nail growth, KRTAP4-6 has also been shown to be involved in the regulation of cell survival and apoptosis. Studies have shown that KRTAP4-6 can induce cell apoptosis in response to various stressors, such as UV radiation and exposure to chemicals. This suggests that KRTAP4-6 may be a potential drug target for diseases that are characterized by cell dysfunction or death.

Another potential application of KRTAP4-6 as a drug target is its role in the development of cancer. Studies have shown that KRTAP4-6 is often overexpressed in various types of cancer, and that this overexpression is associated with poor prognosis. Additionally, KRTAP4-6 has been shown to promote the growth of cancer cells in cell culture, which suggests that it may be a useful biomarker for the evaluation of cancer therapeutic effectiveness.

In addition to its potential as a drug target and biomarker, KRTAP4-6 is also of interest as a potential biomarker for the diagnosis of certain diseases. For example, KRTAP4-6 has been shown to be expressed in the skin tissue of individuals with melanoma, a type of skin cancer. This suggests that KRTAP4-6 may be a useful biomarker for the diagnosis of melanoma.

In conclusion, KRTAP4-6 is a protein that is expressed in a variety of tissues and is involved in the regulation of cell growth and differentiation. Its potential as a drug target and biomarker makes it an attractive target for further research and development. Further studies are needed to fully understand the role of KRTAP4-6 in these processes and its potential as a drug and biomarker.

Protein Name: Keratin Associated Protein 4-6

Functions: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

The "KRTAP4-6 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about KRTAP4-6 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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