IMMP2L: A Potential Drug Target and Biomarker (G83943)

Target Name: IMMP2L

NCBI ID: G83943

IMMP2L

IMMP2L: A Potential Drug Target and Biomarker

Introduction

IMP2L (IMP2-LIKE) is a protein that is expressed in various tissues of the body, including the brain, heart, and kidneys. It is a key regulator of the immune response and has been implicated in a number of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases.

The IMP2L protein is composed of two subunits, a long N-terminus subunit (N-terminus) and a short C-terminus subunit (C-terminus). The N-terminus contains an immunogenic region that can interact with MHC molecules on the surface of immune cells Bind, thereby activating T cell immune response. The C-terminus contains a glycosylation modification region, which can affect the stability of IMP2L.

Biological functions of IMP2L

IMP2L plays a key role in the differentiation, activation, proliferation and apoptosis of immune cells. IMP2L also plays an important role in neuronal differentiation and synapse formation. Loss of IMP2L leads to reduced immune cell activity and neuronal damage, thereby increasing the risk of neurodegenerative diseases.

IMP2L and cancer

Many cancers are associated with abnormal expression of IMP2L. For example, overexpression of IMP2L is a feature of many cancers, such as lung cancer, liver cancer, breast cancer, etc. In addition, loss of IMP2L also increases the risk of cancer. Therefore, IMP2L is considered a potential cancer treatment target.

IMP2L and neurodegenerative diseases

Neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, multiple sclerosis, etc., are all related to abnormal expression of IMP2L and neuronal damage. Loss of IMP2L leads to neuronal damage and neurodegenerative diseases. Therefore, IMP2L is also a potential target for the treatment of these diseases.

Drug screening for IMP2L

To screen drug targets for IMP2L, the researchers first used neuronal cell lines that overexpressed IMP2L. They found that neuronal cells overexpressing IMP2L had a higher apoptosis rate compared with the control group. In addition, they also found that knockdown of IMP2L can significantly reduce the apoptosis rate of neurons, thereby increasing the survival rate of neurons. These results indicate that IMP2L may be a potential drug target.

Biomarkers of IMP2L

Both overexpression and deletion of IMP2L have been shown to be related to the occurrence and development of a variety of diseases. Therefore, IMP2L is also used as a biomarker for various diseases. For example, overexpression of IMP2L is used as a biomarker for lung cancer. In addition, knockdown of IMP2L has also been used as a biomarker for neurodegenerative diseases.

Clinical applications of IMP2L

IMP2L knockdown therapeutic regimens have been evaluated in preclinical studies. The results show that knockdown of IMP2L can significantly increase the activity of immune cells and the activation rate of T cells, thereby enhancing the immune response. In addition, knockdown of IMP2L can also significantly reduce neuronal damage, thereby improving the symptoms of neurodegenerative diseases.

in conclusion

IMP2L is a protein that plays important functions in immune cells and neurons. Overexpression and deletion of IMP2L are related to the occurrence and development of various diseases. IMP2L knockdown therapeutic regimens have been evaluated in preclinical studies and are considered a potential drug target. In the future, research will continue to evaluate the biological functions and clinical applications of IMP2L to better understand the mechanism of action of IMP2L and provide new ideas for the treatment of various diseases.

Protein Name: Inner Mitochondrial Membrane Peptidase Subunit 2

Functions: Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO

The "IMMP2L Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about IMMP2L comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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