Target Name: RNASET2
NCBI ID: G8635
Review Report on RNASET2 Target / Biomarker Content of Review Report on RNASET2 Target / Biomarker
RNASET2
Other Name(s): Ribonuclease 6 | RNASE6PL | bA514O12.3 | ribonuclease T2 | RP11-514O12.3 | Ribonuclease T2 | ribonuclease 6 | RNT2_HUMAN

RNA-Nucleic Acid-Protein Complexes: Extending the Reach of Biomarkers

RNA-Nucleic Acid-Protein (RNA-NAP) complexes have emerged as a promising candidate for drug targets and biomarkers due to their unique structural features and diverse functions in various cellular processes. One of these complexes, Ribonuclease 6 (RNASET2), has garnered significant interest due to its potential role in cancer progression and metastasis. In this article, we will explore the biology of RNASET2, its potential as a drug target and biomarker, and the ongoing research in this field.

The RNASET2 Complex

RNASET2 is a 21 kDa RNA-NAP that consists of the protein RNASET2, the RNA molecule itself, and a small protein called p120RAS. It is expressed in various cell types, including epithelial, hepatocytes, and myocytes, and is involved in various cellular processes, including cell signaling, DNA replication, and repair, cell adhesion, and cell survival.

The RNASET2 complex plays a crucial role in the regulation of gene expression and is responsible for promoting the expression of target genes. It does this by activating the protein p120RAS, which in turn activates the RNA polymerase II (RNA-II) complex, leading to increased transcription of target genes.

Potential Drug Target

The RNASET2 complex has been identified as a potential drug target due to its involvement in various cellular processes that are often disrupted in cancer. For example, RNASET2 has been shown to promote the progression of various types of cancer, including pancreatic, breast, and ovarian cancers. Additionally, it has been linked to the development of cancer stem cells, which are capable of maintaining the growth and survival of cancer tumors.

In addition to its role in cancer progression, RNASET2 has also been shown to contribute to the development of various types of diseases, including neurodegenerative diseases, cardiomyopathies, and autoimmune diseases.

Potential Biomarkers

The RNASET2 complex has also been identified as a potential biomarker for various types of cancer, including pancreatic, breast, and ovarian cancers. The expression of RNASET2 has been shown to increase in various types of cancer, making it a promising target for cancer diagnostics and therapies.

Research and Theoretical Perspectives

Several studies have investigated the role of RNASET2 in various cellular processes, including its effects on cell signaling, DNA replication, and repair, and its contribution to cancer progression. These studies have provided valuable insights into the biology of RNASET2 and have laid the foundation for further research in this field.

One of the most significant findings of recent studies is the involvement of RNASET2 in the regulation of theNotch signaling pathway, which is a well-established regulator of cancer growth and survival. The Notch signaling pathway is involved in the regulation of various cellular processes, including stem cell self-renewal, proliferation, and differentiation, and is a potential target for cancer therapies.

In addition, research has also shown that RNASET2 plays a role in the regulation of theWnt signaling pathway, which is involved in cell-cell signaling and has been implicated in various diseases, including cancer.

Conclusion

In conclusion, the RNASET2 complex has emerged as a promising candidate for drug targets and biomarkers due to its unique structural features and diverse functions in various cellular processes. Its involvement in the regulation of cell signaling, DNA replication, and repair, as well as its potential as a cancer drug target and biomarker, make it an attractive target for further research. Further studies are needed to fully understand the biology of RNASET2 and its potential as a drug

Protein Name: Ribonuclease T2

Functions: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653). Also plays a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs (PubMed:30385512)

The "RNASET2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNASET2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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