Target Name: RNF114
NCBI ID: G55905
Review Report on RNF114 Target / Biomarker Content of Review Report on RNF114 Target / Biomarker
RNF114
Other Name(s): ring finger protein 114 | RN114_HUMAN | Zinc finger protein 313 | Ring finger protein 114 | zinc finger protein 313 | zinc finger protein 228 | Zinc finger protein 228 | RING-type E3 ubiquitin transferase RNF114 | PSORS12 | ZNF313 | RING finger protein 114 | E3 ubiquitin-protein ligase RNF114

Ring Finger Protein 114 (RF114): A Promising Drug Target and Biomarker

Ring finger protein 114 (RF114) is a gene that encodes a protein located at the base of the ring finger on chromosome 5A. It has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. In this article, we will explore the biology and potential therapeutic applications of RF114.

Biography of RF114

The ring finger is a type of gene that is commonly found in humans and other animals. It is responsible for the production of proteins that are involved in various cellular processes, including cell signaling, DNA replication, and protein-protein interactions. The ring finger gene has four exons, which are the first four amino acids that make up the protein.

RF114 is a gene that encodes a protein with 114 amino acids. It has a unique feature, which is the presence of a double-stranded loop at its C-terminus. This loop is composed of the amino acids Asp-21, Asp-22, Asp-23, and Asp-24.

Expression and Localization of RF114

RF114 is expressed in various tissues and cells of the body, including muscle, nerve, heart, and brain cells. It is mainly expressed in the brain, where it is found at the highest levels. RF114 is also expressed in other tissues, including the placenta, where it is involved in the development and maintenance of neural cells.

Function of RF114

RF114 is a protein that is involved in various cellular processes, including cell signaling, protein-protein interactions, and DNA replication. It plays a crucial role in the regulation of cell proliferation and differentiation.

One of the unique features of RF114 is its ability to interact with other proteins. It has been shown to interact with various proteins, including the transcription factor p53. This interaction between RF114 and p53 suggests that RF114 may be involved in the regulation of gene expression.

Another function of RF114 is its role in DNA replication. RF114 has been shown to be involved in the regulation of DNA replication, which is critical for the development and maintenance of cancer cells.

Potential Therapeutic Applications of RF114

RF114 has the potential to be a drug target and biomarker for various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases.

1. Cancer

RF114 has been shown to be involved in the regulation of cell proliferation and the development of cancer cells. It has been shown to interact with the transcription factor p53, which is a key regulator of cancer cell growth.

One of the potential therapeutic applications of RF114 is its use in cancer treatment. By inhibiting the activity of p53, RF114 may be able to inhibit the growth and spread of cancer cells.

2. Neurodegenerative Disorders

RF114 has also been shown to be involved in the development and progression of neurodegenerative disorders. It has been shown to interact with the neurotransmitter receptor NG2, which is involved in the regulation of brain function.

One of the potential therapeutic applications of RF114 is its use in the treatment of neurodegenerative disorders. By interacting with NG2 and regulating the transmission of signals along the nervous system, RF114 may be able to improve the function of neurotransmitters and slow the progression of neurodegenerative disorders.

3. Autoimmune Diseases

RF114 has also been shown to be involved in the development and regulation of autoimmune diseases. It has been shown to interact with the immune system

Protein Name: Ring Finger Protein 114

Functions: E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates (PubMed:23645206, PubMed:25165885). In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity (PubMed:25165885, PubMed:28708287). Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3 (PubMed:25165885). May promote the ubiquitination of TRAF6 as well (PubMed:28708287). Acts also as a negative regulator of T-cell activation (PubMed:25165885). Inhibits cellular dsRNA responses and interferon production by targeting MAVS component for proteasomal degradation (PubMed:25165885). Ubiquitinates the CDK inhibitor CDKN1A leading to its degradationand probably also CDKN1B and CDKN1C (PubMed:23645206). This activity stimulates cell cycle G1-to-S phase transition and suppresses cellular senescence. May play a role in spermatogenesis

The "RNF114 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about RNF114 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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