ZDHHC16: A Potential Drug Target and Biomarker (G84287)

Target Name: ZDHHC16

NCBI ID: G84287

ZDHHC16

ZDHHC16: A Potential Drug Target and Biomarker

Zinc finger (ZNF) genes are a family of non-coding RNAs that play a crucial role in various cellular processes. One of the subfamilies of ZNF genes, the DHHC domain containing 16 (ZDHHC16), has been identified as a potential drug target and biomarker. This gene has unique features that make it an attractive target for drug development due to its involvement in various cellular processes, including cell growth, differentiation, and survival.

The DHHC domain is a conserved region that is found in various proteins, including ZNF genes. It is characterized by a specific sequence that is composed of multiple domains, including a zinc finger, a leucinerich repeat, a domain that interacts with DNA, and a C-terminal domain that contains a unique amino acid sequence. ZDHHC16 is a 21-kDa protein that contains a single copy.

The ZDHHC16 gene has been expressed in various cell types, including mouse, human, and cancer cells. It is highly expressed in the human placenta, which is a critical organ that supports the growth and development of fetal cells. ZDHHC16 has also been shown to be highly expressed in various types of cancer, including breast, ovarian, and colorectal cancer. This suggests that it may be a potential biomarker for cancer diagnosis and treatment.

In addition to its potential as a biomarker, ZDHHC16 has also been shown to be a drug target. Several studies have shown that ZDHHC16 plays a role in various cellular processes, including cell growth, differentiation, and survival. in the regulation of cell proliferation, cell adhesion, and cell survival.

One of the most significant findings related to ZDHHC16 is its role in the regulation of cell survival. Several studies have shown that ZDHHC16 plays a role in the regulation of cell survival by interacting with various cellular signaling pathways, including the TGF-β pathway. This pathway is involved in the regulation of cell growth, differentiation, and survival, and is a key target for many diseases, including cancer.

Another study has shown that ZDHHC16 is involved in the regulation of cell adhesion. Adhesion is the process by which cells stick together and form tissues. ZDHHC16 has been shown to be involved in the regulation of cell adhesion by interacting with the cadherin protein. This protein is involved in cell-cell adhesion and plays a critical role in the regulation of various cellular processes, including cell growth and differentiation.

In addition to its role in cell survival and adhesion, ZDHHC16 has also been shown to be involved in the regulation of cell proliferation. Several studies have shown that ZDHHC16 plays a role in the regulation of cell proliferation by interacting with various cellular signaling pathways, including the PI3K/Akt signaling pathway. This pathway is involved in the regulation of cellular signaling pathways, including cell growth, differentiation, and survival.

The potential drug targets for ZDHHC16 are numerous. One of the most promising targets is the zinc finger domain, which is known for its role in various cellular processes. Zinc fingers are a type of non-coding RNA that contain a specific sequence that is similar to a zinc finger protein. These sequences are conserved across various species and are often involved in the regulation of various cellular processes.

Another potential drug target for ZDHHC16 is the leucinerich repeat, which is a conserved region that is found in various proteins. This region is involved in the regulation of various cellular processes, including

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 16

Functions: Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:28826475). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (PubMed:28826475). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity)

The "ZDHHC16 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC16 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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