ZDHHC2: A Potential Drug Target and Biomarker (G51201)

Target Name: ZDHHC2

NCBI ID: G51201

ZDHHC2

ZDHHC2: A Potential Drug Target and Biomarker

Zinc finger proteins (ZFPs) and their associated domains have been implicated in a wide range of cellular processes, including gene regulation, DNA replication, and cell signaling. One subfamily of ZFPs, the DHHC domain, has been identified in various cellular organisms and is composed of multiple conserved amino acid residues that are involved in protein-protein interactions and other cellular processes. One of these proteins, ZDHHC2, has been shown to be a potential drug target and biomarker in various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Structure and Function of ZDHHC2

ZDHHC2 is a 21-kDa protein that is expressed in various tissues and cells, including liver, pancreas, and brain. It consists of a single open reading frame (ORF) that is primarily composed of three exons. The protein has a characteristic ZFN-like domain, which is composed of a nucleotide-binding oligomerization (NBO) domain, a zinc finger domain, and a variable region.

The NBO domain is a common feature of ZFNs and is responsible for nucleotide binding and oligomerization. In ZDHHC2, this domain is characterized by a specific amino acid sequence that includes a nucleotide-binding oligomerization domain (NBO), a zinc finger domain, and a variable region. The NBO domain is responsible for binding to specific nucleotides and for participating in DNA replication, repair, and other cellular processes.

The zinc finger domain is a conserved structural feature that is involved in protein-protein interactions and is composed of multiple zinc finger repeats. In ZDHHC2, the zinc finger domain is characterized by a specific amino acid sequence that includes a conserved structural motif called the \"ZNF2-like\" motif. This motif is composed of a conserved core region that includes a zinc finger and a variable loop region, as well as a variable side chain that includes a variety of amino acids.

The variable region of ZDHHC2 consists of a series of amino acid residues that are involved in the protein's localization and function. This region includes a short amino acid loop (aa20-22), a long amino acid loop (aa22-51), and a variable amino acid residue (aa53-55). The variable loop region is responsible for the protein's stability and for participating in ZDHHC2's regulation by post-translational modification (PTM).

Expression and Localization of ZDHHC2

ZDHHC2 is expressed in various tissues and cells and has been shown to be involved in a wide range of cellular processes, including DNA replication, gene expression, and cell signaling. For example, studies have shown that ZDHHC2 is involved in the regulation of DNA replication in various organisms, including humans.

In addition to its role in DNA replication, ZDHHC2 has also been shown to be involved in the regulation of gene expression. For example, studies have shown that ZDHHC2 can interact with the transcription factor p53 and can modulate its activity. This interaction between ZDHHC2 and p53 suggests that ZDHHC2 may be involved in the regulation of gene expression.

Furthermore, ZDHHC2 has also been shown to be involved in cell signaling. For example, studies have shown that ZDHHC2 can interact with the protein SIRT1 and can modulate its activity. This interaction between ZDHHC2 and SIRT1 suggests that ZDHHC2 may be involved in the regulation of cellular processes that involve SIRT1.

Potential Therapeutic Applications

The potential therapeutic applications of ZDHHC2 are vast and varied. As a drug target, ZDHHC2 may be used to treat a wide range of diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. For example, studies have shown that inhibiting

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 2

Functions: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes (PubMed:18508921, PubMed:18296695, PubMed:19144824, PubMed:21343290, PubMed:22034844, PubMed:23793055). Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function (PubMed:18508921). Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane (PubMed:18296695, PubMed:19144824). Could also palmitoylate LCK and regulate its localization to the plasma membrane (PubMed:22034844)

The "ZDHHC2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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