ZDHHC19: A Potential Drug Target and Biomarker (G131540)

Target Name: ZDHHC19

NCBI ID: G131540

ZDHHC19

ZDHHC19: A Potential Drug Target and Biomarker

ZDHHC19, also known as ZDHHC19 variant 1, is a protein that is expressed in various tissues of the body, including the brain, heart, liver, and pancreas. It is a member of the Z-DNA binding protein family, which is known for their role in the regulation of gene expression and DNA replication. ZDHHC19 has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

The Z-DNA binding protein family consists of multiple subfamilies, including ZDHHC17, ZDHHC18, and ZDHHC19. These proteins share a conserved catalytic core and a N-terminal transmembrane domain, while their C-terminus variations provide their unique identities. ZDHHC19 is a 19kDa protein that contains 215 amino acid residues. It has been shown to have various functions in various biological processes, including cell adhesion, migration, and invasion.

One of the most significant functions of ZDHHC19 is its role in the regulation of DNA replication. ZDHHC19 is known to interact with the DNA double helix and play a role in the initiation of DNA replication. It has been shown to be involved in the regulation of gene expression, specifically in the genes that are involved in cell growth and differentiation. ZDHHC19 has also been shown to play a role in the regulation of DNA repair, which is essential for the maintenance of genetic integrity in damaged cells.

In addition to its role in DNA replication and repair, ZDHHC19 has also been shown to be involved in the regulation of cell adhesion and migration. It has been shown to interact with various cell adhesion molecules, including cadherins and integrins, and to play a role in the regulation of cell migration. These functions are important for the development and progression of various diseases, including cancer.

The potential drug target for ZDHHC19 is based on its role in cell adhesion and migration. Cancer cells often have increased invasiveness and migratory ability, which allows them to escape from the immune system and promote tumor growth. ZDHHC19 has been shown to be involved in these processes, which makes it a potential target for cancer therapies.

In addition to its potential as a cancer drug target, ZDHHC19 has also been identified as a potential biomarker for various diseases. The ZDHHC19 gene has been shown to be expressed in a variety of tissues and organs, including the brain, heart, liver, and pancreas. This suggests that it may be a useful biomarker for diseases affecting these organs. In addition, ZDHHC19 has been shown to be involved in the regulation of various biological processes, including cell growth and differentiation, which may be relevant to the development and progression of some diseases.

Overall, ZDHHC19 is a protein that has important functions in various biological processes, including cell adhesion, migration, and DNA replication. Its potential as a drug target and biomarker makes it an attractive target for further research and development in the field of medicine. Further studies are needed to fully understand the functions of ZDHHC19 and its potential as a drug and biomarker.

Protein Name: Zinc Finger DHHC-type Palmitoyltransferase 19

Functions: Palmitoyltransferase that mediates palmitoylation of RRAS, leading to increased cell viability

The "ZDHHC19 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about ZDHHC19 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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