Unlocking the Potential of CACNG2: A Drug Target and Biomarker for Cardiovascular Disease

Target Name: CACNG2

NCBI ID: G10369

CACNG2

Unlocking the Potential of CACNG2: A Drug Target and Biomarker for Cardiovascular Disease

Introduction

Cardiovascular disease remains one of the leading causes of morbidity and mortality worldwide, placing a significant burden on public health and economic systems. The development of new therapeutic approaches to treat cardiovascular diseases is crucial for reducing these morbidities and mortality rates. One promising candidate for drug targeting and biomarker identification is the voltage-dependent calcium channel gamma-2 subunit (CACNG2). This article will provide an overview of CACNG2, its potential as a drug target and biomarker, and its clinical implications.

CACNG2: A Mammalian Extremely Conserved Transient Calcium Channel Subunit

CACNG2, also known as voltage-dependent calcium channel subunit alpha-2, is a highly conserved transmembrane protein that plays a critical role in the regulation of intracellular calcium levels. It is a member of the voltage-dependent calcium channels (VDCA) family, which are known to play a central role in various physiological processes, including muscle contractions, neuronal communication, and intracellular signaling. CACNG2 is expressed in a variety of mammalian tissues and is involved in several cellular processes, including cell signaling, neurotransmission, and neurodegeneration.

CACNG2 Functions as a Calcium Channel

CACNG2 is a type of voltage-dependent calcium channel that is characterized by its ability to regulate calcium ion influx in response to changes in membrane potential. This is achieved through a unique conformational change that allows the channel to either open or close, allowing calcium ions to enter or exit the cell. CACNG2 is composed of four transmembrane segments (TMS) that are separated by a disulfide bond. The TMSs are involved in the regulation of the channel's conductivity, as well as its stability and target recognition.

CACNG2 is involved in a wide range of physiological processes in mammals, including muscle contractions, neuronal communication, and intracellular signaling. For example, CACNG2 is involved in the regulation of muscle contractions, allowing muscle fibers to relax and contract in response to changes in neural input. It is also involved in the regulation of neuronal communication, allowing neurons to transmit signals through synapses. Additionally, CACNG2 is involved in intracellular signaling, participating in the regulation of cellular processes such as cell division, apoptosis, and inflammation.

CACNG2 as a Drug Target

CACNG2 has been identified as a potential drug target for a variety of cardiovascular diseases due to its involvement in multiple cellular processes that are involved in cardiovascular disease. The ability of CACNG2 to regulate calcium ion influx and its role in intracellular signaling make it an attractive target for drug development. Several studies have shown that blocking CACNG2 can lead to therapeutic effects in cardiovascular disease, including decreased risk of myocardial infarction, stroke, and neurodegeneration.

CACNG2 has also been shown to be involved in the regulation of several cardiovascular risk factors, including blood pressure, cholesterol levels, and the risk of cardiovascular disease in individuals with diabetes. Several studies have shown that individuals with hypertension, a common risk factor for cardiovascular disease, have lower levels of CACNG2 than those without hypertension. Additionally, individuals with high cholesterol levels and diabetes have higher levels of CACNG2, which may contribute to their increased risk of cardiovascular disease.

CACNG2 as a Biomarker

CACNG2 has also been identified as a potential biomarker for cardiovascular disease due to its involvement in the regulation of multiple cellular processes that are involved in cardiovascular disease. The ability of CACNG2 to regulate calcium ion influx and its role in intracellular signaling make it an attractive target for the development of diagnostic tests. Several studies have shown that measuring CACNG2 levels in peripheral tissues, such as blood vessels and heart muscle, can provide information about the risk of cardiovascular disease.

CACNG2 has also been shown to be involved in

Protein Name: Calcium Voltage-gated Channel Auxiliary Subunit Gamma 2

Functions: Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state

The "CACNG2 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about CACNG2 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets