Target Name: NLRP13
NCBI ID: G126204
Review Report on NLRP13 Target / Biomarker Content of Review Report on NLRP13 Target / Biomarker
NLRP13
Other Name(s): NACHT, LRR and PYD domains-containing protein 13 (isoform 1) | nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13 | NACHT, leucine rich repeat and PYD containing 13 | Nucleotide-binding oligomerization domain protein 14 | NLR family pyrin domain containing 13, transcript variant 1 | NACHT, LRR and PYD domains-containing protein 13 | NALP13 | NACHT, LRR and PYD containing protein 13 | NLRP13 variant 1 | Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 13 | NOD14 | nucleotide-binding oligomerization domain protein 14 | PAN13 | CLR19.7 | NAL13_HUMAN | NLR family pyrin domain containing 13

NLRP13: Potential Drug Target and Cellular Stress Response

NLRP13 (Nacht, LRR and PYD domains-containing protein 13 (isoform 1)) is a protein that plays a crucial role in the regulation of cell death and homeostasis. It is a member of the NLRP1 family, which are known for their involvement in the formation of stress-responsive RNA splicing complexes (SRRCs). NLRP13 is expressed in nearly all eukaryotic cells, including mammals, birds, fish, and fungi. It plays an important role in a variety of physiological processes, such as apoptosis, cell cycle regulation, cell signaling, and cell morphology maintenance.

In recent years, with the deepening of genomic research, it has been found that NLRP13 plays an important role in many diseases. For example, in neurodegenerative diseases, abnormal expression of NLRP13 has been confirmed to be closely related to neuronal loss and neuronal functional impairment. In addition, NLRP13 also plays an important role in tumorigenesis. For example, studies have shown that NLRP13 expression levels correlate with tumor invasiveness and metastasis. Therefore, NLRP13 is considered a potential drug target.

In addition, NLRP13 also plays an important role in cellular stress response. Under stress conditions, a series of signaling molecules are produced in cells, such as the release of inflammatory factors and changes in the cell cycle. These signaling molecules activate NLRP13, triggering a series of biological effects. For example, studies have shown that activation of NLRP13 can inhibit apoptosis, thereby protecting cells under stress conditions.

In addition to its role in cell death and stress response, NLRP13 is also involved in many important biological processes. For example, NLRP13 is an important component in cell cycle regulation. Studies have shown that activation of NLRP13 can increase the length of G1 phase and the proportion of S phase in the cell cycle, thereby promoting cell growth and proliferation. In addition, NLRP13 is also involved in cell adhesion and cell migration. Studies have shown that activation of NLRP13 can increase the ability of cell adhesion and cell migration, thereby playing an important role in tissues and organs.

At present, research on NLRP13 mainly focuses on two aspects: first, the role of NLRP13 in diseases, and second, the potential of NLRP13 as a drug target.

Protein Name: NLR Family Pyrin Domain Containing 13

Functions: Involved in inflammation

The "NLRP13 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NLRP13 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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