NLRC3: A Drug Target / Disease Biomarker (G197358)

Target Name: NLRC3

NCBI ID: G197358

NLRC3

NLRC3: A Drug Target / Disease Biomarker

TheNLRC3 protein is a key regulator of neural stem cell proliferation and differentiation, and has been identified as a potential drug target for various neurological and psychiatric disorders. its structure and function have been extensively studied in the past decade, and its role in various biological processes has become increasingly well understood.

The NLRC3 protein is a member of the K-type hydrolipid transmembrane protein (KHBP) family, which is characterized by the presence of a hydrophobic domain, a long coiled-coil, and a cytoplasmic tail. The NLRC3 protein is approximately 22 kDa in size and has a unique 尾-hairpin structure in the cytoplasmic tail region.

The NLRC3 protein plays a crucial role in the regulation of neural stem cell (NSC) proliferation and differentiation. NSC are a diverse set of cells that have the ability to generate neurons and other glial cells that make up the nervous system. The NLRC3 protein helps to maintain the quiescent state of NSC, by regulating the activities of several key transcription factors, such as Sox2, Ki67, and Pax6.

The NLRC3 protein has also been shown to play a role in the regulation of neuronal excitability. NLRC3 has been shown to interact with the neurotransmitter acetylcholine, which is involved in the regulation of neuronal excitability. This interaction between NLRC3 and acetylcholine has been shown to play a role in the development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.

In addition to its role in NSC proliferation and differentiation, the NLRC3 protein has also been shown to play a role in the regulation of various cellular processes, including cell adhesion, migration, and apoptosis. The NLRC3 protein has been shown to interact with several other proteins, including the transcription factor NF-kappa-B, and the protein T-cell factor (TGF-β).

The NLRC3 protein is also of interest as a potential drug target, due to its role in the regulation of various neurological and psychiatric disorders. The development of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, is a major focus of current drug development, and the NLRC3 protein is thought to be a promising target for these disorders.

In conclusion, the NLRC3 protein is a key regulator of neural stem cell proliferation and differentiation, and has been identified as a potential drug target for various neurological and psychiatric disorders. Further research is needed to fully understand the role of NLRC3 in these processes, as well as its potential as a drug target.

Protein Name: NLR Family CARD Domain Containing 3

Functions: Negative regulator of the innate immune response (PubMed:15705585, PubMed:22863753, PubMed:25277106). Attenuates signaling pathways activated by Toll-like receptors (TLRs) and the DNA sensor STING/TMEM173 in response to pathogen-associated molecular patterns, such as intracellular poly(dA:dT), but not poly(I:C), or in response to DNA virus infection, including that of Herpes simplex virus 1 (HSV1) (By similarity) (PubMed:22863753). May affect TLR4 signaling by acting at the level of TRAF6 ubiquitination, decreasing the activating 'Lys-63'-linked ubiquitination and leaving unchanged the degradative 'Lys-48'-linked ubiquitination (PubMed:22863753). Inhibits the PI3K-AKT-mTOR pathway possibly by directly interacting with the posphatidylinositol 3-kinase regulatory subunit p85 (PIK3R1/PIK3R2) and disrupting the association between PIK3R1/PIK3R2 and the catalytic subunit p110 (PIK3CA/PIK3CB/PIK3CD) and reducing PIK3R1/PIK3R2 activation. Via its regulation of the PI3K-AKT-mTOR pathway, controls cell proliferation, predominantly in intestinal epithelial cells (By similarity). May also affect NOD1- or NOD2-mediated NF-kappa-B activation (PubMed:25277106). Might also affect the inflammatory response by preventing NLRP3 inflammasome formation, CASP1 cleavage and IL1B maturation (PubMed:25277106)

The "NLRC3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NLRC3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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