Target Name: NMBR
NCBI ID: G4829
Review Report on NMBR Target / Biomarker Content of Review Report on NMBR Target / Biomarker
NMBR
Other Name(s): Neuromedin-B receptor (isoform X2) | Neuromedin B receptor, transcript variant 1 | BB1R | Neuromedin B receptor | Neuromedin B receptor, transcript variant X2 | Neuromedin-B-preferring bombesin receptor | Neuromedin-B receptor (isoform a) | Bombesin BB1 (neuromedin B) receptor | epididymis secretory sperm binding protein Li 185a | NMBR_HUMAN | neuromedin-B-preferring bombesin receptor | NMBR variant 1 | NMB-R | Epididymis secretory sperm binding protein Li 185a | neuromedin B receptor | epididymis tissue protein Li 185a | BRS1 | NMBR variant X2 | Neuromedin-B receptor | bombesin receptor 1 | Bombesin receptor 1 | Epididymis tissue protein Li 185a | BB1

Neuromedin-B Receptor: A GPCR Targeted for Neurological Disorders

The Neuromedin-B receptor (ISOform X2) is a G protein-coupled receptor that is expressed in various tissues and plays a crucial role in neuronal function. It is one of the most well-studied GPRs, and its function in neural circuits is highly conserved across species. This protein has been identified as a potential drug target and biomarker for various neurological and psychiatric disorders.

The Neuromedin-B receptor is a member of the G protein-coupled receptor (GPCR) family, which is a large superfamily of transmembrane proteins that play a pivotal role in cellular signaling. GPCRs are composed of a transmembrane domain, an intracellular loop, and an extracellular tail. They are characterized by their ability to modulate various cellular processes, including but not limited to cell growth, differentiation, migration, and neurotransmission.

The Neuromedin-B receptor is a GPCR that is expressed in various tissues, including the brain, pancreas, and heart. It is primarily localized to the basal ganglia, which is a subcortical region of the brain that is responsible for the coordination of motor movements and the regulation of various physiological processes. The Neuromedin-B receptor is also expressed in other tissues, including the retina, where it is involved in the regulation of photoreceptor function.

The Neuromedin-B receptor is involved in a wide range of physiological processes, including but not limited to neuronal function, neurotransmission, and pain modulation. It is highly conserved across species, and its function is highly conserved between humans and other animals. This is evident from the fact that the Neuromedin-B receptor has similar structures and functions in many different species, including humans, mice, and rats.

The Neuromedin-B receptor is a potential drug target and biomarker for various neurological and psychiatric disorders. Its function in neural circuits is highly conserved across species, which makes it an attractive target for drug development. Many studies have identified the Neuromedin-B receptor as a potential drug target for various psychiatric disorders, including depression, anxiety, and schizophrenia. This is because the Neuromedin-B receptor is involved in the regulation of various physiological processes that are affected in these disorders.

For example, research has shown that individuals with depression have decreased levels of the Neuromedin-B receptor in the brain. This suggests that targeting this receptor may be an effective way to treat depression. Similarly, research has shown that individuals with anxiety have increased levels of the Neuromedin-B receptor in the brain. This suggests that targeting this receptor may be an effective way to treat anxiety.

In addition to its potential as a drug target, the Neuromedin-B receptor is also a potential biomarker for various neurological disorders. Its function in neural circuits is highly conserved across species, which makes it an attractive target for the development of biomarkers. Many studies have shown that the Neuromedin-B receptor is involved in the regulation of various physiological processes, including neuronal function, neurotransmission, and pain modulation. This suggests that the Neuromedin-B receptor may be an effective biomarker for a wide range of neurological disorders.

In conclusion, the Neuromedin-B receptor is a GPCR that is involved in a wide range of physiological processes, including but not limited to neuronal function, neurotransmission, and pain modulation. It is a potential drug target and biomarker for various neurological and psychiatric disorders. Its function in neural circuits is highly conserved across species, which makes it an attractive target for drug development. Further research is needed to fully understand the Neuromedin-B receptor's role in neural circuits and its potential as a drug

Protein Name: Neuromedin B Receptor

Functions: Receptor for neuromedin-B (PubMed:1655761). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity)

The "NMBR Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NMBR comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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