Target Name: NLRP12
NCBI ID: G91662
Review Report on NLRP12 Target / Biomarker Content of Review Report on NLRP12 Target / Biomarker
NLRP12
Other Name(s): NLR family pyrin domain containing 12, transcript variant 3 | NLRP12 variant 3 | NACHT, LRR and PYD domains-containing protein 12 (isoform 3) | PYRIN-containing APAF1-like protein 7 mRNA | NLR family pyrin domain containing 12, transcript variant 2 | NLR family pyrin domain containing 12 | monarch 1 | NLRP12 variant 2 | NACHT, LRR and PYD containing protein 12 | NACHT, LRR and PYD domains-containing protein 12 | Monarch 1 | NACHT, LRR and PYD domains-containing protein 12 (isoform 2) | Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 | PYPAF7 | Regulated by nitric oxide | nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 | Leucine-rich-repeat protein | NALP12 | NACHT, leucine rich repeat and PYD containing 12 | PYRIN-containing APAF1-like protein 7 | RNO2 | Monarch-1 | FCAS2 | RNO | regulated by nitric oxide | Monarch1 | PAN6 | NAL12_HUMAN | CLR19.3

NLRP12: Key Protein Involved in Inflammation, Immune Response, DNA Replication and Stress Response

NLRP12 (NLR family pyrin domain containing 12, transcript variant 3) is a protein that plays a crucial role in the regulation of inflammation and immune responses. It is a key player in the non-coding RNA (ncRNA) field, where small interfering RNA (siRNA) plays a significant role in silencing gene expression. NLRP12 is a protein that is composed of 12 amino acids and is localized to the endoplasmic reticulum (ER).

The NLRP12 protein is involved in the formation of a protein-protein interaction (PPI) complex, which is responsible for the regulation of various cellular processes, including cell signaling, DNA replication, and stress responses. NLRP12 is also involved in the regulation of inflammation and immune responses, which are critical for maintaining the health and integrity of the body.

One of the key functions of NLRP12 is its ability to recognize and interact with small RNA species, including siRNAs. SiRNAs are short interfering RNAs that are derived from double-stranded RNA viruses, and they have been shown to play a crucial role in post-transcriptional gene regulation. NLRP12 is known to form a PPI with the RNA-binding protein (RBP) domain, which is responsible for the recognition and interaction with siRNAs.

The RBP domain is a protein that is composed of 21 amino acids and is found in various proteins, including NLRP12. It is known to have a role in the regulation of protein stability and interactions, and is involved in the formation of PPIs with other proteins. The RBP domain is also known to have a role in the regulation of gene expression, and is involved in the formation of PPIs with transcription factors.

NLRP12 is also involved in the regulation of DNA replication, which is a critical process for the development and maintenance of the human genome. NLRP12 is known to form a PPI with the DNA-binding protein (DBP) domain, which is responsible for the recognition and interaction with DNA. DBP is a protein that is composed of 12 amino acids and is located in various proteins, including NLRP12.

NLRP12 is also involved in the regulation of stress responses, which are critical for the maintenance of cellular homeostasis. NLRP12 is known to form a PPI with the stress-responsive protein (StRP) domain, which is responsible for the recognition and interaction with stress-responsive proteins. StRP is a protein that is composed of 20 amino acids and is located in various proteins, including NLRP12.

In conclusion, NLRP12 is a protein that plays a crucial role in the regulation of various cellular processes, including inflammation, immune responses, DNA replication, and stress responses. It is involved in the formation of PPIs with various proteins, including the RBP domain, DBP, and StRP domains. As a result, NLRP12 is a potential drug target and biomarker for various diseases, including cancer, autoimmune diseases, and neurodegenerative diseases. Further research is needed to fully understand the role of NLRP12 in the regulation of cellular processes and its potential as a drug target.

Protein Name: NLR Family Pyrin Domain Containing 12

Functions: Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Inhibits also the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (PubMed:30902577). Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity)

The "NLRP12 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NLRP12 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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