Target Name: NME3
NCBI ID: G4832
Review Report on NME3 Target / Biomarker Content of Review Report on NME3 Target / Biomarker
NME3
Other Name(s): NME/NM23 nucleoside diphosphate kinase 3 | nucleoside diphosphate kinase C | NDP kinase C | NDK 3 | NDP kinase 3 | NDPKC | NM23H3 | nm23-H3 | c371H6.2 | NM23-H3 | Nm23-H3 | Non-metastatic cells 3, protein expressed in | Nucleoside diphosphate kinase 3 | DR-nm23 | NDPK-C | NDK3_HUMAN | Nucleoside diphosphate kinase C | C371H6.2 | non-metastatic cells 3, protein expressed in

NME3: A Drug Target and Biomarker for Nucleoside Diphosphate Kinase 3

Nucleoside diphosphate kinase 3 (NME3) is a protein that plays a crucial role in the regulation of nucleoside diphosphate (NDP) levels in various cell types. NME3 is a key enzyme in the NDP kinase family, which is responsible for the breakdown of NDPs to produce nucleosides, which are the building blocks of DNA and RNA. The NME3 enzyme has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, andurological disorders.

The NME3 enzyme is involved in the regulation of a wide range of cellular processes, including DNA replication, gene expression, and cell survival. NME3 is highly specific for its target, NDPs. It is known to cleave several NDPs, including the major form of NDP, NTP, and APTT. The cleavage of NDPs by NME3 generates a phosphate group, which can then act as a structural component in various cellular processes.

One of the key features of NME3 is its role in the regulation of DNA replication. In DNA replication, NME3 is involved in the formation of the double helix and the extension of the replication strand. NME3 has been shown to play a critical role in the regulation of DNA replication efficiency, by ensuring that the enzyme half cycle is not active, while the other half is active, allowing for accurate and efficient replication.

In addition to its role in DNA replication, NME3 is also involved in the regulation of gene expression. NME3 has been shown to play a critical role in the regulation of gene expression by ensuring that the NTP levels are optimal for protein synthesis. The NME3 enzyme has been shown to cleave NTP and generate a phosphate group, which can then act as a structural component in the synthesizing protein. This ensures that the protein is properly synthesized and can function correctly.

NME3 is also involved in the regulation of cell survival. The NME3 enzyme has been shown to play a critical role in the regulation of cell survival by ensuring that the cell has access to NDPs, which are essential for various cellular processes, including cell signaling, cell division, and DNA replication. The NME3 enzyme has also been shown to play a critical role in the regulation of apoptosis, by ensuring that the cell has access to NDPs, which are essential for the regulation of apoptosis.

In conclusion, NME3 is a protein that plays a crucial role in the regulation of various cellular processes. The NME3 enzyme has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and urological disorders. Further research is needed to fully understand the role of NME3 in cellular processes and to develop effective treatments for various diseases.

Protein Name: NME/NM23 Nucleoside Diphosphate Kinase 3

Functions: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis

The "NME3 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NME3 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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