Target Name: NLRP9
NCBI ID: G338321
Review Report on NLRP9 Target / Biomarker Content of Review Report on NLRP9 Target / Biomarker
NLRP9
Other Name(s): nucleotide-binding oligomerization domain protein 6 | NLRP9_HUMAN | CLR19.1 | NACHT, LRR and PYD domains-containing protein 9 | Nucleotide-binding oligomerization domain protein 6 | Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 9 | PAN12 | NOD6 | NACHT, leucine rich repeat and PYD containing 9 | nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 9 | NALP9 | NLR family pyrin domain containing 9 | PYRIN and NACHT-containing protein 12 | NACHT, LRR and PYD containing protein 9

Understanding NLRP9: A Potential Drug Target for Proteins

NLRP9 (Nucleotide-Binding Oligomerization Domain Protein 9) is a protein that plays a crucial role in the regulation of gene expression and cell signaling. It is a member of the NLRP family of proteins, which are known for their ability to form multiprotein complexes that can alter protein stability and function. NLRP9 is widely expressed in many tissues and is involved in a variety of cellular processes, including DNA damage repair, cell signaling, and inflammation.

One of the key functions of NLRP9 is its ability to form multiprotein complexes with other proteins. These complexes can be formed through a process called nucleotide-binding oligomerization, which allows NLRP9 to bind to specific nucleotides in target proteins. This ability to form multiprotein complexes makes NLRP9 a potentially interesting drug target, as drugs that target NLRP9's activity could potentially have a wide range of therapeutic applications.

In addition to its role in protein regulation, NLRP9 is also involved in several cellular processes that are important for normal development and function. For example, NLRP9 is involved in the regulation of DNA damage repair, which is a critical process that helps cells repair damage to their DNA caused by factors such as exposure to radiation or chemical mutants. NLRP9 is also involved in the regulation of cell signaling, including the production of signaling molecules such as cytokines and chemokines.

In addition to its involvement in cellular signaling, NLRP9 is also involved in the regulation of inflammation. NLRP9 has been shown to play a role in the regulation of immune responses, as well as in the regulation of inflammation-related processes such as inflammation and inflammation-induced pain.

Despite its involvement in a wide range of cellular processes, NLRP9 is not well understood, and much of its function and regulation remains to be explored. NLRP9 is known to be involved in several cellular signaling pathways, including the TGF-β pathway, the PI3K/Akt pathway, and the NF-kappa-B pathway. However, the precise mechanisms by which NLRP9 regulates these pathways are not well understood, and further research is needed to fully understand its function in these processes.

In conclusion, NLRP9 is a protein that plays a crucial role in the regulation of gene expression and cell signaling. Its ability to form multiprotein complexes and its involvement in a wide range of cellular processes make it an attractive target for drug development. Further research is needed to fully understand NLRP9's function and regulation, and to develop effective therapies that target its activity.

Protein Name: NLR Family Pyrin Domain Containing 9

Functions: As the sensor component of the NLRP9 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens, including rotavirus, initiates the formation of the inflammasome polymeric complex, made of NLRP9, PYCARD and CASP1. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and release in the extracellular milieu. The active cytokines stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. NLRP9 inflammasome activation may be initiated by DHX9 interaction with viral double-stranded RNA (dsRNA), preferentially to short dsRNA segments

The "NLRP9 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NLRP9 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

More Common Targets

NLRP9P1 | NLRX1 | NMB | NMBR | NMD3 | NMDA receptor | NME1 | NME1-NME2 | NME2 | NME2P1 | NME3 | NME4 | NME5 | NME6 | NME7 | NME8 | NME9 | NMI | NMNAT1 | NMNAT2 | NMNAT3 | NMRAL1 | NMRAL2P | NMRK1 | NMRK2 | NMS | NMT1 | NMT2 | NMTRQ-TTG10-1 | NMTRQ-TTG12-1 | NMTRV-TAC1-1 | NMU | NMUR1 | NMUR2 | NNAT | NNMT | NNT | NNT-AS1 | NOA1 | NOB1 | NOBOX | NOC2L | NOC2LP2 | NOC3L | NOC4L | NOCT | NOD1 | NOD2 | NODAL | NOG | NOL10 | NOL11 | NOL12 | NOL3 | NOL4 | NOL4L | NOL4L-DT | NOL6 | NOL7 | NOL8 | NOL9 | NOLC1 | NOM1 | NOMO1 | NOMO2 | NOMO3 | Non-protein coding RNA 185 | NONO | NOP10 | NOP14 | NOP14-AS1 | NOP16 | NOP2 | NOP53 | NOP56 | Nop56p-associated pre-rRNA complex | NOP58 | NOP9 | NOPCHAP1 | NORAD | NOS1 | NOS1AP | NOS2 | NOS2P1 | NOS2P2 | NOS2P3 | NOS3 | NOSIP | NOSTRIN | Notch ligands | Notch receptor | Notch Transcriptional Activation Complex | NOTCH1 | NOTCH2 | NOTCH2NLA | NOTCH2NLC | NOTCH3 | NOTCH4 | NOTO | NOTUM