Target Name: NLRP10
NCBI ID: G338322
Review Report on NLRP10 Target / Biomarker Content of Review Report on NLRP10 Target / Biomarker
NLRP10
Other Name(s): Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 | nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10 | PYNOD | Nucleotide-binding oligomerization domain protein 8 | NACHT, LRR and PYD domains-containing protein 10 | NLRP10 variant 2 | NALP10 | NACHT, leucine rich repeat and PYD containing 10 | CLR11.1 | NLR family pyrin domain containing 10 | PAN5 | NLR family pyrin domain containing 10, transcript variant 2 | NAL10_HUMAN | NOD8 | nucleotide-binding oligomerization domain protein 8

NLRP10: A Protein Involved in Cell Signaling and Disease

NLRP10 (Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10) is a protein that plays a crucial role in cell signaling and is composed of three domains: nucleotide-binding oligomerization domain (NBD), leucine rich repeat (LRR), and pyrin domain. NLRP10 is a member of the NLRP family, which are known for their role in regulating stress responses and cytoskeletal organization.

The NBD domain is responsible for binding nucleotides with high affinity, allowing it to participate in various DNA-protein interactions. The LRR and Pyrin domains give NLRP10 its unique structure and function. The LRR domain is a 21 amino acid long sequence that contains a leucine-rich repeat, which is a conserved motif that is involved in protein-protein interactions. The Pyrin domain is a 24 amino acid long sequence that contains a specific sequence of amino acids that is involved in protein-protein interactions and is responsible for the formation of a distinct protein-protein interface.

NLRP10 is a protein that is expressed in many different tissues and cells, including the brain, spinal cord, and pancreas. It is involved in various cellular processes, including cell signaling, DNA repair, and stress response. One of NLRP10's most well-known functions is its role in the regulation of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.

Recent studies have suggested that NLRP10 may be a drug target or biomarker for various diseases. For example, research has shown that NLRP10 may be involved in the development and progression of neurodegenerative diseases. Studies have also shown that NLRP10 may be involved in the regulation of cellular stress responses, which could make it a potential target for drugs that are designed to treat stress-related diseases.

In addition to its potential role as a drug target or biomarker, NLRP10 is also a potential therapeutic target for various diseases. For example, research has shown that NLRP10 may be involved in the development and progression of various types of cancer, including breast cancer and colon cancer. Studies have also shown that NLRP10 may be involved in the regulation of cellular processes that are associated with aging, such as the accumulation of beta-amyloid peptides in the brain.

Overall, NLRP10 is a protein that is involved in a variety of cellular processes and has been shown to play a crucial role in the regulation of various diseases. As a result, it is a potential drug target or biomarker for a variety of diseases. Further research is needed to fully understand the functions of NLRP10 and its potential as a therapeutic target.

Protein Name: NLR Family Pyrin Domain Containing 10

Functions: Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID (PubMed:15096476). Displays anti-inflammatory activity (PubMed:20393137). Required for immunity against C.albicans infection (By similarity). Involved in the innate immune response by contributing to pro-inflammatory cytokine release in response to invasive bacterial infection (PubMed:22672233). Contributes to T-cell-mediated inflammatory responses in the skin (By similarity). Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens (PubMed:28766990). Exhibits both ATPase and GTPase activities (PubMed:23861819)

The "NLRP10 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NLRP10 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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