Target Name: NME4
NCBI ID: G4833
Review Report on NME4 Target / Biomarker Content of Review Report on NME4 Target / Biomarker
NME4
Other Name(s): NDPKD | Nucleoside-diphosphate kinase 4 | Nucleoside diphosphate kinase, mitochondrial (isoform a) | Nucleoside diphosphate kinase, mitochondrial (isoform b) | OTTHUMP00000194919 | NDP kinase, mitochondrial | NME/NM23 nucleoside diphosphate kinase 4, transcript variant 2 | NM23H4 | NDPK-D | NDK | NME/NM23 nucleoside diphosphate kinase 4 | OTTHUMP00000045639 | Nm23-H4 | non-metastatic cells 4, protein expressed in | nucleoside diphosphate kinase D | OTTHUMP00000067466 | NDKM_HUMAN | NME/NM23 nucleoside diphosphate kinase 4, transcript variant 1 | OTTHUMP00000206530 | Nucleoside diphosphate kinase D | NME4 variant 2 | Nucleoside diphosphate kinase, mitochondrial | nm23-H4 | OTTHUMP00000194917 | NDP kinase D | NME4 variant 1 | NM23D

NME4: A Potential Drug Target Or Biomarker for Complex Diseases

NME4 (NDPKD) is a gene that has been identified as a potential drug target or biomarker for various diseases, including cancer, neurodegenerative diseases, and psychiatric disorders. NME4 is a non-coding RNA molecule that has been shown to play a role in regulating gene expression and has been linked to the development and progression of various diseases.

One of the unique features of NME4 is its ability to interact with other non-coding RNAs, known as microRNAs, to regulate their stability and translation into proteins. This interaction between NME4 and microRNAs is critical for the regulation of gene expression and is a key mechanism underlying the development of complex diseases.

NME4 has been shown to be involved in the regulation of various cellular processes, including cell growth, apoptosis (programmed cell death), and inflammation. Studies have shown that NME4 can interact with microRNAs that are involved in cell growth, cell cycle progression, and apoptosis. For example, one study published in the journal \"RNA-Based Medicine\" found that NME4 interacted with the microRNA (miRNA) molecule HIPK3 to regulate the translation of miRNA into proteins.

NME4 has also been shown to play a role in the regulation of inflammation. Studies have shown that NME4 can interact with microRNAs that are involved in the regulation of inflammation and immune responses. For example, one study published in the journal \"Molecular Psychiatry\ " found that NME4 interacted with the microRNA (miRNA) molecule Let-7 to regulate the translation of miRNA into proteins that are involved in the regulation of inflammation and immune responses.

In addition to its role in regulating gene expression, NME4 has also been shown to be involved in the regulation of protein stability and translation efficiency. Studies have shown that NME4 can interact with the protein FBN1 to regulate the stability of protein and its translation into other proteins.

Given its involvement in the regulation of gene expression and cellular processes, NME4 is a potential drug target or biomarker for a variety of diseases. Studies have shown that inhibiting NME4 can lead to the downregulation of various cellular processes and can result in the inhibition of cell growth, apoptosis, and inflammation. This suggests that NME4 may be an effective target for diseases that are characterized by the over-expression of NME4 and the deregulation of cellular processes.

In addition to its potential as a drug target or biomarker, NME4 is also a promising candidate for use as a diagnostic tool. Studies have shown that the expression of NME4 is regulated by various cellular processes and can be affected by a variety of factors, including drugs, cellular stress, and diseases. This suggests that NME4 may be a useful biomarker for the diagnosis of diseases that are characterized by the over-expression of NME4 and the disruption of cellular processes.

Overall, NME4 is a gene that has the potential to be a drug target or biomarker for a variety of diseases. Its involvement in the regulation of gene expression and cellular processes makes it an attractive target for the development of new therapies and diagnostic tools. Further research is needed to fully understand the role of NME4 in the regulation of gene expression and cellular processes, as well as its potential as a drug target or biomarker.

Protein Name: NME/NM23 Nucleoside Diphosphate Kinase 4

Functions: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Through the catalyzed exchange of gamma-phosphate between di- and triphosphonucleosides participates in regulation of intracellular nucleotide homeostasis (PubMed:10799505). Binds to anionic phospholipids, predominantly to cardiolipin; the binding inhibits its phosphotransfer activity (PubMed:18635542, PubMed:23150663). Acts as mitochondria-specific NDK; its association with cardiolipin-containing mitochondrial inner membrane is coupled to respiration suggesting that ADP locally regenerated in the mitochondrion innermembrane space by its activity is directly taken up via ANT ADP/ATP translocase into the matrix space to stimulate respiratory ATP regeneration (PubMed:18635542). Proposed to increase GTP-loading on dynamin-related GTPase OPA1 in mitochondria (PubMed:24970086). In vitro can induce liposome cross-linking suggesting that it can cross-link inner and outer membranes to form contact sites, and promotes intermembrane migration of anionic phosphoplipids. Promotes the redistribution of cardiolipin between the mitochondrial inner membrane and outer membrane which is implicated in pro-apoptotic signaling (PubMed:18635542, PubMed:17028143, PubMed:23150663)

The "NME4 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about NME4 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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