Target Name: GPR151
NCBI ID: G134391
Review Report on GPR151 Target / Biomarker Content of Review Report on GPR151 Target / Biomarker
GPR151
Other Name(s): GALR4 | Probable G-protein coupled receptor 151 | G protein-coupled receptor 151 (GPR151) | GALRL | GalRL | GP151_HUMAN | GPCR-2037 | PGR7 | G-protein coupled receptor 151 | Galanin-receptor-like protein | galanin receptor 4 | G-protein coupled receptor PGR7 | Putative G-protein coupled receptor | galanin-receptor-like protein | Galanin receptor 4 | GPCR | G protein-coupled receptor 151

GPR151: A GPCR Targeted for Drug Development Due To Its Unique Structure and Signaling Pathways

GPR151 (GALR4) is a G protein-coupled receptor (GPCR) that is expressed in various tissues and cells in the body. It is a key regulator of sensory perception and neurotransmission, and its function is crucial for the normal functioning of the nervous system . GPR151 is also a potential drug target (or biomarker) due to its unique structure and the involvement of various signaling pathways.

GPR151 is a member of the GPCR family, which includes over 700 different GPCRs that are involved in a wide range of physiological processes in the body. GPCRs are characterized by an extracellular domain that includes a transmembrane segment and an intracellular segment that contains a catalytic protein and a regulatory protein. The transmembrane segment is responsible for maintaining the integrity of the receptor and for providing it with a target for ligand binding, while the intracellular segment contains the regulatory protein, which communicates the signal from the receptor to downstream signaling pathways.

GPR151 is a type of GPCR that is expressed in the nervous system, including the brain, spinal cord, and peripheral tissues. It is involved in the regulation of a wide range of physiological processes, including sensory perception, neurotransmission, and behavior. GPR151 is also involved in the regulation of ion channels, which are critical for the flow of electrical signals through the nervous system.

One of the unique features of GPR151 is its structure. GPCRs can have a wide range of different structures, and GPR151 is no exception. Its transmembrane segment is made up of four 伪-helices, which are arranged in a specific arrangement to form a transmembrane domain. The intracellular segment is made up of a single protein that contains a nucleotide-binding oligomerization (NBO) domain and a G protein-coupled receptor (GPCR) domain. The NBO domain is responsible for interacting with the nucleotides in the intracellular segment, while the GPCR domain is responsible for transmitting the signal from the intracellular segment to downstream signaling pathways.

GPR151 is involved in many different signaling pathways in the nervous system. One of the most well-studied functions of GPR151 is its role in the regulation of sensory perception. GPR151 is involved in the perception of pain, anxiety, and other types of sensory stimuli . For example, GPR151 has been shown to play a role in the regulation of pain sensitivity in response to experimental pain. In addition, GPR151 is involved in the regulation of anxiety and stress, and has been shown to contribute to the development of anxiety- like behaviors in animals.

GPR151 is also involved in the regulation of neurotransmission, which is the process by which neurons communicate with each other. GPR151 is involved in the regulation of neurotransmitter release from neurons and in the regulation of neurotransmitter receptors. For example, GPR151 has been shown to play a role in the regulation of dopamine release from neurons in response to neurotransmitter agonists.

In addition to its involvement in sensory perception and neurotransmission, GPR151 is also involved in the regulation of behavior. GPR151 is involved in the regulation of fear and anxiety-like behaviors, and has been shown to play a role in the development of anxiety disorders in animals.

GPR151 is a potential drug target (or biomarker) due to its unique structure and the involvement of various signaling pathways. GPR151 has been shown to play a

Protein Name: G Protein-coupled Receptor 151

Functions: Proton-sensing G-protein coupled receptor

The "GPR151 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about GPR151 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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