Protein kinase C (nonspecified subtype) Related Diseases

Protein kinase C (nonspecified subtype)

Related Diseases

1) Arthritis
Arthritis, also known as inflammatory joint disease, is related to rheumatoid arthritis and juvenile rheumatoid arthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Arthritis is SYK (Spleen Associated Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Entecavir and Chlorhexidine have been mentioned in the context of this disorder. Affiliated tissues include joint, bone and bone marrow, and related phenotypes are Decreased Tat-dependent HIV-LTR-beta-galactosidase protein expression and homeostasis/metabolism

2) Huntington's Disease
Huntington Disease, also known as huntington's disease, is related to huntington disease-like 1 and choreatic disease, and has symptoms including back pain, headache and myoclonus. An important gene associated with Huntington Disease is HTT (Huntingtin), and among its related pathways/superpathways is miRNAs involved in DNA damage response. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include Brain, eye and globus pallidus, and related phenotypes are chorea and mental deterioration

3) Stroke
Cerebrovascular Disease, also known as cerebrovascular disorder, is related to basal ganglia cerebrovascular disease and stroke, ischemic, and has symptoms including headache, transient ischemic attacks, stereotypic symptoms and angina pectoris. An important gene associated with Cerebrovascular Disease is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Signal Transduction and Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs). The drugs Acetylcarnitine and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include brain, bone marrow and heart, and related phenotypes are homeostasis/metabolism and growth/size/body region

4) Niemann-Pick Disease, Type C
Niemann-Pick Disease, Type C1, also known as niemann-pick disease, type c, is related to niemann-pick disease type c, juvenile neurologic onset and niemann-pick disease type c, adult neurologic onset, and has symptoms including cerebellar ataxia, muscle spasticity and seizures. An important gene associated with Niemann-Pick Disease, Type C1 is NPC1 (NPC Intracellular Cholesterol Transporter 1), and among its related pathways/superpathways are Neuroscience and "Plasma lipoprotein assembly, remodeling, and clearance". The drugs Miglustat and Anti-Infective Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, bone marrow and liver, and related phenotypes are dysphagia and jaundice

5) Diabetes Type 2
Type 2 Diabetes Mellitus, also known as insulin resistance, is related to diabetes mellitus and maturity-onset diabetes of the young, type 8, with exocrine dysfunction, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Type 2 Diabetes Mellitus is IRS1 (Insulin Receptor Substrate 1), and among its related pathways/superpathways are Nervous system development and Angiopoietin-like protein 8 regulatory pathway. The drugs Glipizide and Glycopyrronium have been mentioned in the context of this disorder. Affiliated tissues include Pancreas and Adipose, and related phenotypes are type ii diabetes mellitus and insulin resistance

6) Coronary Artery Disease
Coronary Heart Disease 1, also known as coronary heart disease, is related to angina pectoris and abdominal obesity-metabolic syndrome 1, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Coronary Heart Disease 1 is CX3CR1 (C-X3-C Motif Chemokine Receptor 1), and among its related pathways/superpathways are Metabolism and Transport of inorganic cations/anions and amino acids/oligopeptides. The drugs Simvastatin and Lovastatin have been mentioned in the context of this disorder. Affiliated tissues include Limb and Bone, and related phenotypes are Increased free cholesterol and Increased LDL uptake

7) Atherosclerosis
Atherosclerosis Susceptibility, also known as atherosclerosis, is related to cerebral atherosclerosis and generalized atherosclerosis, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Atherosclerosis Susceptibility is ATHS (Atherosclerosis Susceptibility (Lipoprotein Associated)), and among its related pathways/superpathways are "Plasma lipoprotein assembly, remodeling, and clearance" and Interleukin-4 and Interleukin-13 signaling. The drugs Enalaprilat and Enalapril have been mentioned in the context of this disorder. Affiliated tissues include Heart, and related phenotypes are hypertriglyceridemia and myocardial infarction

8) Rett Syndrome
Rett Syndrome, also known as atypical rett syndrome, is related to developmental and epileptic encephalopathy 2 and chromosome 16p13.3 deletion syndrome, proximal, and has symptoms including back pain, cachexia and constipation. An important gene associated with Rett Syndrome is MECP2 (Methyl-CpG Binding Protein 2), and among its related pathways/superpathways are Signal Transduction and ESR-mediated signaling. The drugs Guaifenesin and Dextromethorphan have been mentioned in the context of this disorder. Affiliated tissues include brain, eye and skeletal muscle, and related phenotypes are eeg abnormality and sleep disturbance

9) Asthma
Asthma, also known as chronic obstructive asthma, is related to allergic asthma and childhood-onset asthma, and has symptoms including recurring periods of wheezing, chest tightness and shortness of breath. An important gene associated with Asthma is IL13 (Interleukin 13), and among its related pathways/superpathways are Allograft rejection and Interleukin-4 and Interleukin-13 signaling. The drugs Fentanyl and Etomidate have been mentioned in the context of this disorder. Affiliated tissues include Lung, smooth muscle and skin, and related phenotypes are asthma and bronchoconstriction

10) Multiple Sclerosis
Multiple Sclerosis, also known as ms, is related to pediatric multiple sclerosis and autoimmune hepatitis, and has symptoms including back pain, headache and hemiplegia. An important gene associated with Multiple Sclerosis is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Phosphorylation of CD3 and TCR zeta chains and Cell differentiation - expanded index. The drugs Acetaminophen and Promethazine have been mentioned in the context of this disorder. Affiliated tissues include Neural Tube and Limb, and related phenotypes are spasticity and diplopia

11) Multiple Myeloma
Myeloma, Multiple, also known as multiple myeloma, is related to monoclonal gammopathy of uncertain significance and plasma cell neoplasm. An important gene associated with Myeloma, Multiple is LIG4 (DNA Ligase 4), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Busulfan and Levofloxacin have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are osteopenia and pathologic fracture

12) Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphocytic, also known as chronic lymphocytic leukemia, is related to richter's syndrome and chronic lymphocytic leukemia/small lymphocytic lymphoma, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Lymphocytic is TP53 (Tumor Protein P53), and among its related pathways/superpathways are miRNA regulation of DNA damage response and DNA damage response (only ATM dependent). The drugs Valganciclovir and Ofatumumab have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are cellular immunodeficiency and chronic lymphatic leukemia

13) Parkinson's Disease
Parkinson Disease, Late-Onset, also known as parkinson disease, is related to hereditary late-onset parkinson disease and parkinson disease 3, autosomal dominant, and has symptoms including angina pectoris, back pain and headache. An important gene associated with Parkinson Disease, Late-Onset is MAPT (Microtubule Associated Protein Tau), and among its related pathways/superpathways is Parkinson's disease pathway. The drugs Idebenone and Tadalafil have been mentioned in the context of this disorder. Affiliated tissues include Brain, and related phenotypes are hallucinations and abnormal autonomic nervous system physiology

14) Angina Pectoris
Angina Pectoris, also known as prinzmetal's variant angina, is related to polycythemia vera and intermittent claudication, and has symptoms including other and unspecified angina pectoris An important gene associated with Angina Pectoris is EDN1 (Endothelin 1), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Candesartan cilexetil and Amiodarone have been mentioned in the context of this disorder. Affiliated tissues include heart, smooth muscle and bone marrow, and related phenotypes are homeostasis/metabolism and muscle

15) Myocardial Infarction
Myocardial Infarction, also known as heart attack, is related to lipoprotein quantitative trait locus and cardiovascular system disease, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Myocardial Infarction is MIAT (Myocardial Infarction Associated Transcript), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Antiviral and anti-inflammatory effects of Nrf2 on SARS-CoV-2 pathway. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Bone and Limb.

16) Heart Failure
Congestive Heart Failure, also known as congestive heart disease, is related to cardiomyopathy, dilated, 1e and orthostatic intolerance, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Congestive Heart Failure is CDKN2B-AS1 (CDKN2B Antisense RNA 1), and among its related pathways/superpathways are Cardiac conduction and "Antiarrhythmic Pathway, Pharmacodynamics". The drugs Salbutamol and Thalidomide have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Lateral Plate Mesoderm, and related phenotypes are muscle and homeostasis/metabolism

17) Acute Myeloid Leukemia
Acute Myeloblastic Leukemia with Maturation, also known as acute myeloblastic leukemia type 2, is related to myeloid leukemia and myeloid sarcoma. An important gene associated with Acute Myeloblastic Leukemia with Maturation is MIR181A1HG (MIR181A1 Host Gene), and among its related pathways/superpathways are Ras signaling and Hematopoietic Stem Cells and Lineage-specific Markers. The drugs Nicotine and Amsacrine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Decreased substrate adherent cell growth and Decreased substrate adherent cell growth

18) Chronic Lymphocytic Leukemia
Leukemia, Chronic Lymphocytic 2, also known as leukemia, chronic lymphocytic, susceptibility to, 2, is related to chronic lymphocytic leukemia/small lymphocytic lymphoma and chromosomal triplication, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia, Chronic Lymphocytic 2 is CLLS2 (Disrupted In B-Cell Neoplasia), and among its related pathways/superpathways are Hematopoietic Stem Cells and Lineage-specific Markers and Interleukin-4 and Interleukin-13 signaling. The drugs Valganciclovir and Chlorambucil have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and b cells, and related phenotypes are chronic lymphatic leukemia and immune system

19) Contact Dermatitis
Contact Dermatitis, also known as contact dermatitis/eczema, is related to irritant dermatitis and nickel allergic contact dermatitis, and has symptoms including exanthema and pruritus. An important gene associated with Contact Dermatitis is IL31 (Interleukin 31), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Clobetasol and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and lymph node, and related phenotypes are homeostasis/metabolism and immune system

20) Duchenne Muscular Dystrophy
Muscular Dystrophy, Duchenne Type, also known as duchenne muscular dystrophy, is related to muscular dystrophy, becker type and facioscapulohumeral muscular dystrophy 1, and has symptoms including waddling gait and weakness. An important gene associated with Muscular Dystrophy, Duchenne Type is DMD (Dystrophin), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involvement in the immune response in sepsis. The drugs Carvedilol and Ramipril have been mentioned in the context of this disorder. Affiliated tissues include Adipose and Umbilical Cord, and related phenotypes are scoliosis and respiratory insufficiency

21) Meniere's Disease
Meniere Disease, also known as meniere's disease, is related to otosclerosis and inner ear disease, and has symptoms including coughing, snoring and tinnitus. An important gene associated with Meniere Disease is FAM136A (Family With Sequence Similarity 136 Member A). The drugs Tocopherol and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and adrenal cortex, and related phenotypes are hearing impairment and vertigo

22) Hairy Cell Leukemia
Classic Hairy Cell Leukemia, also known as leukemic reticuloendotheliosis, is related to intrapelvic lymph node leukemic reticuloendotheliosis and reticuloendotheliosis, x-linked. An important gene associated with Classic Hairy Cell Leukemia is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase). The drugs Cladribine and 2-chloro-3'-deoxyadenosine have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, spleen and bone.

23) Lymphoma
Lymphosarcoma, also known as lymphoma, diffuse, is related to lymphoma, non-hodgkin, familial and lymphoma, hodgkin, classic. An important gene associated with Lymphosarcoma is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Direct p53 effectors and Interleukin-4 and Interleukin-13 signaling. The drugs Crofelemer and Aprepitant have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid.

24) Inflammatory Bowel Disease
Inflammatory Bowel Disease, also known as inflammatory bowel diseases, is related to inflammatory bowel disease 6 and inflammatory bowel disease 9. An important gene associated with Inflammatory Bowel Disease is IL37 (Interleukin 37). The drugs Copper and Zinc cation have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and bone marrow.

25) Anxiety Disorders
Anxiety, also known as anxiety disorders, is related to generalized anxiety disorder and separation anxiety disorder, and has symptoms including nervousness, agitation and feeling tense. An important gene associated with Anxiety is SLC6A4 (Solute Carrier Family 6 Member 4), and among its related pathways/superpathways are Signal Transduction and Class A/1 (Rhodopsin-like receptors). The drugs Amlodipine and Lorazepam have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and thyroid, and related phenotypes are nervous system and normal

26) Atopic Dermatitis
Dermatitis, Atopic, also known as atopic dermatitis, is related to allergic disease and dermatitis, atopic, 3, and has symptoms including exanthema and pruritus. An important gene associated with Dermatitis, Atopic is FLG (Filaggrin), and among its related pathways/superpathways are MIF Mediated Glucocorticoid Regulation and Cytokine Signaling in Immune system. The drugs Zinc oxide and Coal tar have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast, and related phenotypes are cataract and ichthyosis

27) Hyperparathyroidism
Hyperparathyroidism, also known as hyperparathyroidism and other disorders of parathyroid gland, is related to hyperparathyroidism 1 and hyperparathyroidism 2 with jaw tumors. An important gene associated with Hyperparathyroidism is HRPT3 (Hyperparathyroidism 3), and among its related pathways/superpathways are Signal Transduction and G alpha (s) signalling events. The drugs Benzocaine and Tannic acid have been mentioned in the context of this disorder. Affiliated tissues include kidney, bone and thyroid, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

28) Gynecomastia
Gynecomastia is related to 17-beta hydroxysteroid dehydrogenase iii deficiency and androgen insensitivity, partial. An important gene associated with Gynecomastia is CYP19A1 (Cytochrome P450 Family 19 Subfamily A Member 1), and among its related pathways/superpathways are Metabolism of proteins and Signal Transduction. The drugs (R)-Bicalutamide and Tamoxifen have been mentioned in the context of this disorder. Affiliated tissues include breast, prostate and testis, and related phenotypes are homeostasis/metabolism and nervous system

29) Pain
Paine Syndrome, also known as pain disorder, is related to paroxysmal extreme pain disorder and indifference to pain, congenital, autosomal recessive. An important gene associated with Paine Syndrome is HFE (Homeostatic Iron Regulator), and among its related pathways/superpathways are Cardiac conduction and Neuropathic Pain-Signaling in Dorsal Horn Neurons. The drugs Pregabalin and Dinoprostone have been mentioned in the context of this disorder. Affiliated tissues include dorsal root ganglion, spinal cord and breast, and related phenotypes are microcephaly and spastic diplegia

30) Spasticity
Spasticity is related to spastic paraplegia 41, autosomal dominant and spastic paraplegia 19, autosomal dominant. An important gene associated with Spasticity is SPAST (Spastin), and among its related pathways/superpathways is Sudden infant death syndrome (SIDS) susceptibility pathways. The drugs Memantine and Dopamine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord, brain and skeletal muscle, and related phenotypes are nervous system and growth/size/body region

31) Cancer, Breast
Breast Cancer, also known as breast carcinoma, is related to ovarian cancer and hereditary breast ovarian cancer syndrome, and has symptoms including pelvic pain, lameness, animal and pain. An important gene associated with Breast Cancer is BRCA2 (BRCA2 DNA Repair Associated), and among its related pathways/superpathways are Gene expression (Transcription) and ERK Signaling. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include breast, lymph node and prostate, and related phenotypes are breast carcinoma and Decreased viability

32) Cancer, Prostate
Prostate Cancer, also known as prostate carcinoma, is related to breast cancer and prostate disease, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Prostate Cancer is CHEK2 (Checkpoint Kinase 2), and among its related pathways/superpathways are Endometrial cancer and Breast cancer pathway. The drugs Sodium citrate and Sildenafil have been mentioned in the context of this disorder. Affiliated tissues include prostate, bone and lymph node, and related phenotypes are prostate cancer and neoplasm

33) Cancer, Brain
Brain Cancer, also known as malignant neoplasm of brain, is related to li-fraumeni syndrome and lung cancer, and has symptoms including back pain, headache and pain. An important gene associated with Brain Cancer is MIR142 (MicroRNA 142), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Fentanyl and Dexmedetomidine have been mentioned in the context of this disorder. Affiliated tissues include brain, breast and lung, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

34) Cancer, Colon
Colorectal Cancer, also known as colon cancer, is related to lynch syndrome and colonic benign neoplasm, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Colorectal Cancer is CTNNB1 (Catenin Beta 1), and among its related pathways/superpathways are Disease and ERK Signaling. The drugs Tramadol and Ferrous fumarate have been mentioned in the context of this disorder. Affiliated tissues include colon, rectum and liver, and related phenotypes are renal cell carcinoma and neoplasm of the stomach

35) Cancer, Bladder
Bladder Cancer, also known as urinary bladder cancer, is related to bladder urothelial carcinoma and costello syndrome. An important gene associated with Bladder Cancer is FGFR3 (Fibroblast Growth Factor Receptor 3), and among its related pathways/superpathways are Breast cancer pathway and MAPK Signaling: Mitogens. The drugs Tamsulosin and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include urinary bladder, lymph node and prostate, and related phenotypes are transitional cell carcinoma of the bladder and bladder neoplasm

36) Carcinoma, Squamous Cell
Squamous Cell Carcinoma, also known as carcinoma, squamous cell, is related to squamous cell carcinoma, head and neck and esophageal cancer. An important gene associated with Squamous Cell Carcinoma is DDR2 (Discoidin Domain Receptor Tyrosine Kinase 2). The drugs Petrolatum and Mometasone furoate have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and tongue.

37) Epilepsy
Epilepsy, also known as epilepsy syndrome, is related to epilepsy, myoclonic juvenile and childhood absence epilepsy, and has symptoms including back pain, headache and pain. An important gene associated with Epilepsy is SCN1A (Sodium Voltage-Gated Channel Alpha Subunit 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Ethosuximide and Vigabatrin have been mentioned in the context of this disorder. Affiliated tissues include brain, temporal lobe and thalamus, and related phenotypes are nervous system and growth/size/body region

38) Leukemia
Leukemia, also known as leukaemia, unspecified, without mention of remission, is related to myeloid leukemia and leukemia, chronic myeloid, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Leukemia is MIR27A (MicroRNA 27a), and among its related pathways/superpathways are NF-kappaB Signaling and Imatinib and chronic myeloid leukemia. The drugs Azacitidine and Decitabine have been mentioned in the context of this disorder. Affiliated tissues include myeloid, bone marrow and t cells, and related phenotypes are Increased HDAC inhibitor resistance and endocrine/exocrine gland

39) Cutaneous T-cell Lymphoma
Primary Cutaneous T-Cell Non-Hodgkin Lymphoma, also known as cutaneous t-cell lymphoma, is related to primary cutaneous gamma-delta t-cell lymphoma and parapsoriasis. An important gene associated with Primary Cutaneous T-Cell Non-Hodgkin Lymphoma is TNFRSF8 (TNF Receptor Superfamily Member 8), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Levoleucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone marrow, and related phenotypes are no effect and no effect

40) Sleep Disorder
Sleep Disorder, also known as sleep disorders, is related to narcolepsy 1 and idiopathic hypersomnia, and has symptoms including back pain, cachexia and cyanosis. An important gene associated with Sleep Disorder is HCRT (Hypocretin Neuropeptide Precursor), and among its related pathways/superpathways are IL-9 Signaling Pathways and Peptide hormone metabolism. The drugs Tramadol and Ketamine have been mentioned in the context of this disorder. Affiliated tissues include heart, brain and lung, and related phenotypes are no effect and no effect

41) Glioma
Glial Tumor, also known as glioma, is related to optic nerve glioma and brain stem glioma. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, t cells and bone marrow.

42) Graft-versus-host Disease
Graft-Versus-Host Disease, also known as graft-versus-host disease, susceptibility to, is related to bronchiolitis obliterans and acute graft versus host disease. An important gene associated with Graft-Versus-Host Disease is IL10 (Interleukin 10), and among its related pathways/superpathways are Cytokine Signaling in Immune system and PAK Pathway. The drugs Tacrolimus and Lomustine have been mentioned in the context of this disorder. Affiliated tissues include Bone, bone marrow and t cells, and related phenotypes are elevated hepatic transaminase and skin erosion

43) Rheumatoid Arthritis
Rheumatoid Arthritis, also known as ra, is related to arthritis and psoriatic arthritis, and has symptoms including back pain, muscle cramp and sciatica. An important gene associated with Rheumatoid Arthritis is PTPN22 (Protein Tyrosine Phosphatase Non-Receptor Type 22), and among its related pathways/superpathways are NF-kappaB Signaling and Genes associated with the development of rheumatoid arthritis. The drugs Entecavir and Alendronic acid have been mentioned in the context of this disorder. Affiliated tissues include Cartilage, joint and bone, and related phenotypes are joint stiffness and fatigue

44) Myeloid Leukemia
Myeloid Leukemia, also known as myeloid leukaemia, is related to leukemia, acute myeloid and leukemia, chronic myeloid. An important gene associated with Myeloid Leukemia is MIR99AHG (Mir-99a-Let-7c Cluster Host Gene), and among its related pathways/superpathways are HIF-1-alpha transcription factor network and Wnt/beta-catenin signaling pathway in leukemia. The drugs Nicotine and Mitoxantrone have been mentioned in the context of this disorder. Affiliated tissues include myeloid tissue, myeloid and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

45) Schizophrenia
Schizophrenia, also known as schizophrenia with or without an affective disorder, is related to schizoaffective disorder and psychotic disorder, and has symptoms including sleep disturbances, photophobia and personality changes. An important gene associated with Schizophrenia is RTN4R (Reticulon 4 Receptor), and among its related pathways/superpathways are "Methylphenidate Pathway, Pharmacodynamics" and MTHFR deficiency. The drugs Molindone and Asenapine have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and cortex, and related phenotypes are eeg abnormality and hallucinations

46) Diabetes
Diabetes Mellitus, also known as diabetes, is related to type 2 diabetes mellitus and gestational diabetes, and has symptoms including angina pectoris, tremor and equilibration disorder. An important gene associated with Diabetes Mellitus is KCNJ11 (Potassium Inwardly Rectifying Channel Subfamily J Member 11), and among its related pathways/superpathways are Regulation of beta-cell development and Cell differentiation - expanded index. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include pancreas, bone marrow and kidney.

47) Diabetic Nephropathy
Microvascular Complications of Diabetes 2, also known as microvascular complications of diabetes, susceptibility to, 2, is related to microvascular complications of diabetes 3 and background diabetic retinopathy. An important gene associated with Microvascular Complications of Diabetes 2 is EPO (Erythropoietin). The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include kidney, endothelial and retina.

48) Diabetic Macular Edema
Diabetic Macular Edema is related to vitreous detachment and retinal detachment. An important gene associated with Diabetic Macular Edema is VEGFA (Vascular Endothelial Growth Factor A), and among its related pathways/superpathways are Apoptotic Pathways in Synovial Fibroblasts and ERK Signaling. The drugs Dipivefrin and Diclofenac have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and retina, and related phenotypes are homeostasis/metabolism and nervous system

49) Systemic Lupus Erythematosus
Systemic Lupus Erythematosus, also known as lupus nephritis, is related to lupus erythematosus and autoimmune disease, and has symptoms including exanthema, pruritus and lupus-like rash. An important gene associated with Systemic Lupus Erythematosus is TREX1 (Three Prime Repair Exonuclease 1), and among its related pathways/superpathways are Innate Immune System and NF-kappaB Signaling. The drugs Sulfamethoxazole and Trimethoprim have been mentioned in the context of this disorder. Affiliated tissues include Umbilical Cord, bone marrow and skin, and related phenotypes are lupus nephritis and arthritis

50) Systemic Mastocytosis
Systemic Mastocytosis, also known as systemic mast cell disease, is related to systemic mastocytosis with associated hematologic neoplasm and indolent systemic mastocytosis. An important gene associated with Systemic Mastocytosis is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and ERK Signaling. The drugs Protein Kinase Inhibitors and Imatinib Mesylate have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and spleen, and related phenotypes are Decreased viability and Decreased viability

51) Fibrosis
Fibrosis of Extraocular Muscles, Congenital, 1, also known as fibrosis of extraocular muscles, congenital, 3b, is related to moebius syndrome and fibrosis of extraocular muscles, congenital, 2, and has symptoms including cachexia, cyanosis and dyspnea. An important gene associated with Fibrosis of Extraocular Muscles, Congenital, 1 is KIF21A (Kinesin Family Member 21A), and among its related pathways/superpathways are Class I MHC mediated antigen processing and presentation and Vesicle-mediated transport. The drugs Angiotensin II and Losartan have been mentioned in the context of this disorder. Affiliated tissues include liver, eye and bone marrow, and related phenotypes are esotropia and exotropia

52) Ischemia
Ischemia, also known as acute coronary syndrome, is related to limb ischemia and lipoprotein quantitative trait locus, and has symptoms including anoxemia, polydipsia and muscle weakness. An important gene associated with Ischemia is LINC01254 (Long Intergenic Non-Protein Coding RNA 1254), and among its related pathways/superpathways are Signal Transduction and Response to elevated platelet cytosolic Ca2+. The drugs Lovastatin and Nadroparin have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, heart and brain, and related phenotypes are homeostasis/metabolism and nervous system

53) Sarcoma
Malignant Mesenchymoma, also known as malignant mesenchymal tumor, is related to gallbladder sarcoma and leiomyosarcoma. An important gene associated with Malignant Mesenchymoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Mesenchymal Stem Cells and Lineage-specific Markers and Myogenesis. The drugs Ritonavir and Lopinavir have been mentioned in the context of this disorder. Affiliated tissues include t cells, uterus and bone, and related phenotype is muscle.

54) Liver Diseases
Liver Disease, also known as liver diseases, is related to non-alcoholic fatty liver disease and fatty liver disease, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Liver Disease is MEG3 (Maternally Expressed 3), and among its related pathways/superpathways are Metabolism and Nuclear receptors meta-pathway. The drugs Perindopril and Amlodipine have been mentioned in the context of this disorder. Affiliated tissues include liver, bone marrow and kidney, and related phenotypes are Reduced mammosphere formation and liver/biliary system

55) Mast Cell Leukemia
Mast-Cell Leukemia, also known as mast cell leukemia, is related to mastocytosis, cutaneous and mast-cell sarcoma. An important gene associated with Mast-Cell Leukemia is KIT (KIT Proto-Oncogene, Receptor Tyrosine Kinase), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Mycophenolic acid and Fludarabine have been mentioned in the context of this disorder. Affiliated tissues include peripheral blood, bone marrow and spleen, and related phenotypes are Decreased viability and Decreased viability

56) Renal Failure
Kidney Disease, also known as renal failure, is related to chronic kidney disease and polycystic kidney disease, and has symptoms including polyuria An important gene associated with Kidney Disease is TSC1 (TSC Complex Subunit 1), and among its related pathways/superpathways are Ciliopathies and Bardet-Biedl syndrome. The drugs Amiodarone and Nicotinamide have been mentioned in the context of this disorder. Affiliated tissues include kidney, heart and bone marrow, and related phenotypes are homeostasis/metabolism and renal/urinary system

57) Gastrointestinal Disorders
Gastrointestinal System Disease, also known as gastrointestinal disease, is related to crohn's disease and stomach disease, and has symptoms including peeling tongue, catarrh and blood in stool. An important gene associated with Gastrointestinal System Disease is MIR199A1 (MicroRNA 199a-1), and among its related pathways/superpathways are Cell differentiation - expanded index and miRNAs involved in DNA damage response. The drugs Indomethacin and Racepinephrine have been mentioned in the context of this disorder. Affiliated tissues include gastrointestinal tract, small intestine and liver.

58) Fragile X Syndrome
Fragile X Syndrome, also known as martin-bell syndrome, is related to fragile x tremor/ataxia syndrome and autism spectrum disorder, and has symptoms including seizures and agitation. An important gene associated with Fragile X Syndrome is FMR1 (Fragile X Messenger Ribonucleoprotein 1), and among its related pathways/superpathways are Neuropathic Pain-Signaling in Dorsal Horn Neurons and Neuroscience. The drugs Lovastatin and Riluzole have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and prefrontal cortex, and related phenotypes are neurological speech impairment and chronic otitis media

59) Alopecia
Alopecia is related to alopecia universalis congenita and alopecia-mental retardation syndrome 1, and has symptoms including exanthema and pruritus. An important gene associated with Alopecia is SASH1 (SAM And SH3 Domain Containing 1), and among its related pathways/superpathways are Direct p53 effectors and Validated transcriptional targets of TAp63 isoforms. The drugs Cetirizine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include Hair, and related phenotypes are no effect and no effect

60) Autoimmune Disease
Autoimmune Disease, also known as autoimmune diseases, is related to vitiligo-associated multiple autoimmune disease susceptibility 1 and systemic lupus erythematosus. An important gene associated with Autoimmune Disease is AIS4 (Autoimmune Disease, Susceptibility To, 4), and among its related pathways/superpathways are Innate Immune System and MIF Mediated Glucocorticoid Regulation. The drugs Sofosbuvir and Ledipasvir have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and skin, and related phenotypes are autoimmune antibody positivity and endocrine/exocrine gland

61) Mycosis Fungoides
Mycosis Fungoides, also known as mycosis fungoides lymphoma, is related to lymphoproliferative syndrome, x-linked, 1 and lymphoma. An important gene associated with Mycosis Fungoides is CTLA4 (Cytotoxic T-Lymphocyte Associated Protein 4), and among its related pathways/superpathways are Innate Immune System and Signal Transduction. The drugs Denileukin diftitox and Levoleucovorin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and bone marrow, and related phenotypes are dry skin and neoplasm of the skin

62) Thrombosis
Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy, also known as chaple, is related to blood group, cromer system and protein-losing enteropathy. An important gene associated with Complement Hyperactivation, Angiopathic Thrombosis, and Protein-Losing Enteropathy is CD55 (CD55 Molecule (Cromer Blood Group)). The drugs Dabigatran and Norethisterone have been mentioned in the context of this disorder. Affiliated tissues include liver, whole blood and endothelial, and related phenotypes are thrombocytosis and hepatomegaly

63) Retinopathy, Diabetic
Microvascular Complications of Diabetes 5, also known as diabetic retinopathy, is related to microvascular complications of diabetes 1 and type 1 diabetes mellitus. An important gene associated with Microvascular Complications of Diabetes 5 is PON1 (Paraoxonase 1), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Mecobalamin and Hydroxocobalamin have been mentioned in the context of this disorder. Affiliated tissues include Eye, and related phenotypes are homeostasis/metabolism and cardiovascular system

64) Keratosis, Actinic
Actinic Keratosis, also known as solar keratosis, is related to keratosis and squamous cell carcinoma. An important gene associated with Actinic Keratosis is TP63 (Tumor Protein P63), and among its related pathways/superpathways are Toll-like receptor signaling pathway and Toll-Like receptor Signaling Pathways. The drugs Prilocaine and Bacitracin have been mentioned in the context of this disorder. Affiliated tissues include skin, kidney and liver, and related phenotypes are endocrine/exocrine gland and neoplasm

65) Keratosis, Seborrheic
Keratosis, Seborrheic, also known as seborrheic keratosis, is related to inflamed seborrheic keratosis and clear cell acanthoma. An important gene associated with Keratosis, Seborrheic is PIK3CA (Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Alpha), and among its related pathways/superpathways are Endometrial cancer and Burn wound healing. The drugs Hydrogen peroxide and Pharmaceutical Solutions have been mentioned in the context of this disorder. Affiliated tissues include skin, liver and cervix, and related phenotypes are epidermal nevus and seborrheic keratosis

66) Bipolar Disorder
Bipolar Disorder, also known as depression, bipolar, is related to bipolar i disorder and schizophrenia. An important gene associated with Bipolar Disorder is MAFD1 (Major Affective Disorder 1), and among its related pathways/superpathways are Neurotransmitter clearance and "Methylphenidate Pathway, Pharmacodynamics". The drugs Coal tar and Eleuthero have been mentioned in the context of this disorder. Affiliated tissues include brain, prefrontal cortex and eye, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

67) Psoriasis
Psoriasis is related to psoriasis 7 and psoriasis 10, and has symptoms including exanthema, pruritus and psoriasiform rash. An important gene associated with Psoriasis is MIR203A (MicroRNA 203a), and among its related pathways/superpathways are miRNAs involvement in the immune response in sepsis and Cell differentiation - expanded index. The drugs Metformin and Vedolizumab have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and endothelial.

68) Hodgkin Lymphoma
Lymphoma, Hodgkin, Classic, also known as hodgkin lymphoma, is related to mantle cell lymphoma and primary cutaneous t-cell non-hodgkin lymphoma. An important gene associated with Lymphoma, Hodgkin, Classic is KLHDC8B (Kelch Domain Containing 8B), and among its related pathways/superpathways are miRNAs involved in DNA damage response and ncRNAs involved in STAT3 signaling in hepatocellular carcinoma. The drugs Miconazole and Clotrimazole have been mentioned in the context of this disorder. Affiliated tissues include Blood, and related phenotypes are fatigue and immunodeficiency

69) Glaucoma
Intraocular Pressure Quantitative Trait Locus, also known as glaucoma, is related to primary angle-closure glaucoma and open-angle glaucoma. An important gene associated with Intraocular Pressure Quantitative Trait Locus is ZEB1 (Zinc Finger E-Box Binding Homeobox 1), and among its related pathways/superpathways are Clear cell renal cell carcinoma pathways and BMP signaling in eyelid development. The drugs Topiramate and Bromfenac have been mentioned in the context of this disorder. Affiliated tissues include Eye, retina and bone marrow, and related phenotypes are homeostasis/metabolism and nervous system

70) Non-Hodgkin Lymphoma
Lymphoma, also known as non-hodgkin malignant lymphoma nos, is related to lymphoma, hodgkin, classic and lymphoma, non-hodgkin, familial. An important gene associated with Lymphoma is PTPN11 (Protein Tyrosine Phosphatase Non-Receptor Type 11), and among its related pathways/superpathways are IL-9 Signaling Pathways and NF-kappaB Signaling. The drugs Ferrous succinate and Posaconazole have been mentioned in the context of this disorder. Affiliated tissues include t cells, bone marrow and myeloid, and related phenotypes are immune system and hematopoietic system

71) Osteoarthritis
Osteoarthritis, also known as osteoarthrosis, is related to cartilage disease and exostosis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Osteoarthritis is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are ECM proteoglycans and Extracellular matrix organization. The drugs Fentanyl and Benzocaine have been mentioned in the context of this disorder. Affiliated tissues include Cartilage and Bone, and related phenotype is limbs/digits/tail.

72) Osteoporosis
Bone Mineral Density Quantitative Trait Locus 8, also known as osteoporosis, is related to osteoporosis and bone mineral density quantitative trait locus 15, and has symptoms including angina pectoris, back pain and muscle cramp. An important gene associated with Bone Mineral Density Quantitative Trait Locus 8 is BMND8 (Bone Mineral Density Quantiative Trait Locus 8). The drugs Clobetasol and Hydrocortisone have been mentioned in the context of this disorder. Affiliated tissues include bone, bone marrow and spinal cord.

73) Myelodysplasia
Myelodysplastic Syndrome, also known as myelodysplastic syndromes, is related to leukemia, acute myeloid and juvenile myelomonocytic leukemia. An important gene associated with Myelodysplastic Syndrome is TET2 (Tet Methylcytosine Dioxygenase 2), and among its related pathways/superpathways is Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. The drugs Posaconazole and Micafungin have been mentioned in the context of this disorder. Affiliated tissues include Placenta and Umbilical Cord, and related phenotypes are myelodysplasia and neoplasm

74) Ocular Hypertension
Ocular Hypertension, also known as intraocular pressure increase, is related to open-angle glaucoma and intraocular pressure quantitative trait locus, and has symptoms including eye manifestations An important gene associated with Ocular Hypertension is MYOC (Myocilin), and among its related pathways/superpathways are Cellular responses to stimuli and Signal Transduction. The drugs Dipivefrin and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and endothelial, and related phenotypes are homeostasis/metabolism and nervous system

75) Hyperinsulinemia
Hyperinsulinism, also known as hyperinsulinemia, is related to hyperinsulinemic hypoglycemia, familial, 2 and hyperinsulinemic hypoglycemia, familial, 6. An important gene associated with Hyperinsulinism is HNF4A (Hepatocyte Nuclear Factor 4 Alpha), and among its related pathways/superpathways are Translation Insulin regulation of translation and Glucose / Energy Metabolism. The drugs Lanreotide and Mecobalamin have been mentioned in the context of this disorder. Affiliated tissues include ovary, skeletal muscle and liver, and related phenotypes are no effect and no effect

76) Hypertension
Hypertension, Essential, also known as essential hypertension, is related to pulmonary hypertension and renovascular hypertension, and has symptoms including angina pectoris, chest pain and edema. An important gene associated with Hypertension, Essential is PTGIS (Prostaglandin I2 Synthase), and among its related pathways/superpathways are Development Angiotensin activation of ERK and "Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics". The drugs Digoxin and Warfarin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are elevated systolic blood pressure and elevated diastolic blood pressure

77) Melanoma
Melanoma, also known as malignant melanoma, is related to skin melanoma and melanoma, cutaneous malignant 1, and has symptoms including exanthema and pruritus. An important gene associated with Melanoma is BRAF (B-Raf Proto-Oncogene, Serine/Threonine Kinase), and among its related pathways/superpathways are ERK Signaling and Signal Transduction. The drugs Vindesine and Triamcinolone have been mentioned in the context of this disorder. Affiliated tissues include skin, lymph node and t cells, and related phenotypes are normal and pigmentation

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