Heat-Regulated Microbead-Associated Protein (HBBP) as A Potential Drug Target and Biomarker

Target Name: TMEM158

NCBI ID: G25907

TMEM158

Heat-Regulated Microbead-Associated Protein (HBBP) as A Potential Drug Target and Biomarker

TMEM158 (HBBP), a gene encoding a protein known as heat-regulated microbead-associated protein (HBBP), has been identified as a potential drug target and biomarker for various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Its unique function as a heat-regulated protein, which is expressed in response to thermal stress, makes it an attractive target for the development of novel therapeutics.

The HBBP gene was first identified in the late 1990s by researchers at the University of California, San Diego (UCSD) as a heat-regulated gene that was expressed in response to thermal stress, such as heat or cold shock. The HBBP protein is composed of 164 amino acids and has a calculated molecular weight of 19.9 kDa. It is localized to the cytoplasm and is predominantly expressed in the perimyelium, a type of tissue found in the central nervous system that is responsible for maintaining the structural integrity of the brain and spinal cord.

HBBP has been shown to play a critical role in the regulation of cellular processes that are associated with thermal stress, including the stress response, cell division, and apoptosis (programmed cell death). It has also been shown to be involved in the development and progression of various diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

One of the key features of HBBP is its ability to be regulated by temperature. HBBP is heat-regulated by the addition of a heat-responsive phosphate group at its C-terminus, which allows it to be easily targeted by therapeutic agents that are designed to induce heat stress. This feature makes HBBP an attractive target for the development of theragnostics and therapeutic agents that can specifically target and modulate the activity of this protein.

In addition to its potential therapeutic applications, HBBP is also a valuable biomarker for the diagnosis and monitoring of thermal stress-related diseases. The ability of HBBP to be regulated by temperature makes it an attractive candidate for the development of diagnostic tests that can measure the expression and activity of this protein in response to thermal stress. This can be useful for the diagnosis of a variety of thermal stress-related diseases, including cancer, neurodegenerative diseases, and autoimmune disorders.

Another promising aspect of HBBP is its potential to be used as a target for drug development in neurodegenerative diseases. Neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, are characterized by the progressive loss of brain cells and the development of neurofibrillary tangles and neuroplasmic tangles. HBBP has been shown to be involved in the development and progression of these diseases, and its potential therapeutic applications in these fields are being explored.

Furthermore, HBBP has also been shown to be involved in the regulation of cellular processes that are critical for brain development and function. It has been shown to be involved in the regulation of cell survival and proliferation, as well as the formation of axons and dendrites in the brain. This suggests that HBBP may be a potential target for the development of drugs that can modulate these processes and improve brain function in neurodegenerative diseases.

In conclusion, TMEM158 (HBBP) is a gene encoding a protein that is expressed in response to thermal stress and has been shown to play a critical role in the regulation of cellular processes that are associated with this stress. Its unique function and its potential as a drug target and biomarker make it an attractive target for the development of novel therapeutics for the treatment of thermal stress-related diseases, including cancer, neurodegenerative diseases, and autoimmune disorders. Further research is needed to fully understand the role of HBBP in these diseases and

Protein Name: Transmembrane Protein 158

Functions: Receptor for brain injury-derived neurotrophic peptide (BINP), a synthetic 13-mer peptide

The "TMEM158 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM158 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
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•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
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•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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