TMEM145: A Transmembrane Protein as a Potential Drug Target and Biomarker

Target Name: TMEM145

NCBI ID: G284339

TMEM145

TMEM145: A Transmembrane Protein as a Potential Drug Target and Biomarker

TMEM145 is a protein located in the endoplasmic reticulum (ER) and is involved in various cellular processes, including cell signaling, protein transport, and intracellular signaling. Its function and regulation have been extensively studied, and its potential as a drug target or biomarker continue to attract researchers' interest. In this article, we will provide an overview of TMEM145, its function, its potential drug targets, and its potential as a biomarker for various diseases.

Function and Putative Functions

TMEM145 is a 21-kDa transmembrane protein that consists of an extracellular domain, a transmembrane domain, and an intracellular domain. It is expressed in various cell types and is involved in various cellular processes, including cell signaling, protein transport, and intracellular signaling. TMEM145 functions as a protein that can interact with various signaling molecules, including tyrosine kinases, phosphatidylinositol (PI)3-kinases, and G protein-coupled receptors.

One of the putative functions of TMEM145 is as a drug target. The protein is known to interact with various signaling molecules, including PI3K未, which is a key regulator of cell signaling. TMEM145 has been shown to play a role in regulating cell proliferation, apoptosis, and autophagy, and its dysfunction has been linked to various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Potential Drug Targets

TMEM145 has several potential drug targets, including:

1. PI3K未: TMEM145 has been shown to interact with PI3K未 and regulate its activity. Activation of PI3K未 has been shown to promote cell proliferation and survival, while inhibition of PI3K未 has been shown to inhibit these effects. Therefore, inhibitors of PI3K未 could be potential drugs for various diseases, including cancer and neurodegenerative diseases.
2. PDGF-尾: TMEM145 has been shown to interact with PDGF-尾 and regulate its activity. Activation of PDGF-尾 has been shown to promote cell proliferation and survival, while inhibition of PDGF-尾 has been shown to inhibit these effects. Therefore, inhibitors of PDGF-尾 could be potential drugs for various diseases, including cancer and neurodegenerative diseases.
3. TGF-β: TMEM145 has been shown to interact with TGF-β and regulate its activity. Activation of TGF-β has been shown to promote cell proliferation and survival, while inhibition of TGF-β has been shown to inhibit these effects. Therefore, inhibitors of TGF-β could be potential drugs for various diseases, including cancer and neurodegenerative diseases.

Potential Biomarkers

TMEM145 has potential as a biomarker for various diseases. Its function in cell signaling and protein transport make it an attractive candidate for biomarkers that can be used to diagnose or monitor diseases.

1. Cancer: TMEM145 has been shown to play a role in regulating cell proliferation and apoptosis in various cancer types. Its dysfunction has been linked to the development and progression of cancer. Therefore, TMEM145 could be used as a biomarker for cancer, including breast, lung, and ovarian cancers.
2. Neurodegenerative Diseases: TMEM145 has been shown to play a role in the development and progression of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. Its dysfunction has been linked to the development and progression of these diseases. Therefore, TMEM145 could be used as a biomarker for neurodegenerative diseases.
3. Autoimmune Diseases: TMEM145 has been shown to play a role in the development and progression of autoimmune diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Its dysfunction has been linked to the development and progression of these diseases. Therefore, TMEM145 could be used as a biomarker for autoimmune diseases.

Conclusion

TMEM145 is a transmembrane protein that is involved in various cellular processes and has putative functions as a drug target and biomarker. Its function and regulation continue to attract researchers' interest, and its potential as a drug target and biomarker for various diseases continues to be explored. Further research is needed to fully understand TMEM145's role in cell signaling and its potential as a drug target and biomarker for various diseases.

Protein Name: Transmembrane Protein 145

The "TMEM145 Target / Biomarker Review Report" is a customizable review of hundreds up to thousends of related scientific research literature by AI technology, covering specific information about TMEM145 comprehensively, including but not limited to:
•   general information;
•   protein structure and compound binding;
•   protein biological mechanisms;
•   its importance;
•   the target screening and validation;
•   expression level;
•   disease relevance;
•   drug resistance;
•   related combination drugs;
•   pharmacochemistry experiments;
•   related patent analysis;
•   advantages and risks of development, etc.
The report is helpful for project application, drug molecule design, research progress updates, publication of research papers, patent applications, etc. If you are interested to get a full version of this report, please feel free to contact us at BD@silexon.ai

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