Neudesin: A Protein Target for Small Molecules and The ER-TOM Complex

Target Name: NENF

NCBI ID: G29937

NENF

Neudesin: A Protein Target for Small Molecules and The ER-TOM Complex

Neudesin, a protein located in the endoplasmic reticulum (ER), plays a crucial role in the regulation of gene expression and cell signaling. Its function is highly conserved across various species, making it an attractive drug target for researchers. In this article, we will discuss the biology of Neudesin, its functions, and its potential as a drug target.

Neudesin was first identified in the early 1980s as a protein that was specifically expressed in the ER and was shown to interact with several transcription factors, including nuclear factor of NF-Y, Runx1, and p53. The ER is a protein complex that plays a vital role in the production and delivery of proteins to the cytoplasm. The ER is composed of two distinct types of organelles, the endoplasmic reticulum protein (ERP) and the transmembrane protein (TMP).

ERP is the cytoplasmic portion of the ER and is responsible for the sorting of proteins into the ER-TOM complex. TMP is the transmembrane portion of the ER and is involved in the regulation of protein traffic into and out of the ER.

Neudesin is a 21-kDa protein that is predominantly composed of two distinct subunits, alpha-subunit and beta-subunit. The alpha-subunit is responsible for the interaction with transcription factors, while the beta-subunit is involved in the regulation of protein stability and localization to the ER.

Neudesin's functions are highly conserved across various species, making it an attractive drug target. Its ability to interact with multiple transcription factors makes it a potential target for small molecules that can modulate gene expression. Additionally, its localization to the ER makes it an attractive target. for drugs that are targeting the ER-TOM complex.

One of the key functions of Neudesin is its role in the regulation of gene expression. Neudesin interacts with transcription factors to regulate the translation of mRNAs into the cytoplasm. This interaction between Neudesin and transcription factors is critical for the regulation of gene expression, including the Regulation of cell signaling pathways and cellular processes such as cell division, apoptosis, and inflammation.

Neudesin's regulation of gene expression is highly conserved across various species, making it an attractive target for drugs that can modulate gene expression. For example, inhibitors of the Neudesin-NF-Y complex have been shown to be effective in the treatment of various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases.

Another function of Neudesin is its role in the regulation of protein stability and localization to the ER. Neudesin is involved in the regulation of protein stability by interacting with the protein stability and localization (PSL) factor, which is responsible for the stability and localization of many proteins to the ER.

Neudesin's regulation of protein stability and localization to the ER is critical for the regulation of protein function and the production of properly processed proteins that are essential for cellular processes. In addition, its involvement in the regulation of protein stability and localization to the ER makes it an attractive target for drugs that are targeting the ER-TOM complex.

In conclusion, Neudesin is a protein that plays a crucial role in the regulation of gene expression and protein stability and localization to the ER. Its functions make it an attractive target for small molecules that can modulate gene expression and target the ER-TOM complex. Further research is needed to fully understand the biology of Neudesin and its potential as a drug target.

Protein Name: Neudesin Neurotrophic Factor

Functions: Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival (PubMed:31536960). Promotes cell proliferation and neurogenesis in undifferentiated neural progenitor cells at the embryonic stage and inhibits differentiation of astrocytes (By similarity). Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways (By similarity). Neurotrophic activity is enhanced by binding to heme (By similarity). Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity)

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